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Q3APY5 (SYL_CHLCH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Cag_1688
OrganismChlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP]
Taxonomic identifier340177 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium

Protein attributes

Sequence length805 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 805805Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009320

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif576 – 5805"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5791ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3APY5 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: A0C78B83732AF54C

FASTA80592,007
        10         20         30         40         50         60 
MKYDFTSIEK KWQTRWQAEA TFATGTDHSK PKYYVLDMFP YPSGSGLHVG HLEGYTASDI 

        70         80         90        100        110        120 
IARYKRSSGY NVLHPMGWDA FGLPAEQFAI KTGTHPRITT EANVKNFKGT LQAMGFSYDW 

       130        140        150        160        170        180 
EREINTTDSG YFKWTQWIFL QLYDRGLAYM SEVDVNWCEE LKTVLANEEV DEKLADGYTV 

       190        200        210        220        230        240 
VRRPLRQWVL KITAYAERLL ADLEELDWPE NVKQMQRNWI GRSEGVEIDF ELRCHRTTLK 

       250        260        270        280        290        300 
AYTTRPDTLF GATYLVIAPE HPMAEKLATA PQLLVVKEYI TKAKLKSDLE RTGLQKEKSG 

       310        320        330        340        350        360 
VFTGSYAINP ATGQPLPIWI SDFVLISYGT GAIMSVPAHD SRDWAFAKQY NLPIIEVIKS 

       370        380        390        400        410        420 
PHDVQEAVFE EKNSTCVNSA NDEISLNGLD FATAFERMAT WLESKKVGKR KVNYKLRDWI 

       430        440        450        460        470        480 
FSRQRYWGEP IPIKHYEDGT IRPETNLPLE LPAVEAYHPT STGESPLANI TEWLIGNDEH 

       490        500        510        520        530        540 
GAFRRETNTM PQWAGSCWYY LRFIDPHNHA QVVDGNNERY WMNVDLYIGG AEHAVLHLLY 

       550        560        570        580        590        600 
SRFWHKVLYD LGVVSTKEPF QKLFNQGMIL GEDNEKMSKS RGNVIPADHV LQRYGADAVR 

       610        620        630        640        650        660 
LYEMFLGPLE QVKPWNTNGI EGISRFLGKV WRFVYPEHSE AATQPSNEPL PDELLRRMHK 

       670        680        690        700        710        720 
TIKKVGDDTS SLKFNTAIAE MMVFVNELTK TGCNNREAIE TLLKLLAPYA PHMTEELWEA 

       730        740        750        760        770        780 
LGHTNSISHE PFPTFNPALV EENMAIIAVQ VNGKLRGTFT VPAKSPKEML LEEARKVESV 

       790        800 
AKFLEGKTIV KEIVVPDKLV NFAVK 

« Hide

References

[1]"Complete sequence of Chlorobium chlorochromatii CaD3."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CaD3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000108 Genomic DNA. Translation: ABB28940.1.
RefSeqYP_379983.1. NC_007514.1.

3D structure databases

ProteinModelPortalQ3APY5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340177.Cag_1688.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB28940; ABB28940; Cag_1688.
GeneID3746378.
KEGGcch:Cag_1688.
PATRIC21371119. VBIChlChl46571_1754.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycCCHL340177:GHBW-1704-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_CHLCH
AccessionPrimary (citable) accession number: Q3APY5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries