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Q3APY5

- SYL_CHLCH

UniProt

Q3APY5 - SYL_CHLCH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCHL340177:GHBW-1704-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Cag_1688
    OrganismiChlorobium chlorochromatii (strain CaD3)
    Taxonomic identifieri340177 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
    ProteomesiUP000002708: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Leucine--tRNA ligasePRO_1000009320Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340177.Cag_1688.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3APY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3APY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDFTSIEK KWQTRWQAEA TFATGTDHSK PKYYVLDMFP YPSGSGLHVG    50
    HLEGYTASDI IARYKRSSGY NVLHPMGWDA FGLPAEQFAI KTGTHPRITT 100
    EANVKNFKGT LQAMGFSYDW EREINTTDSG YFKWTQWIFL QLYDRGLAYM 150
    SEVDVNWCEE LKTVLANEEV DEKLADGYTV VRRPLRQWVL KITAYAERLL 200
    ADLEELDWPE NVKQMQRNWI GRSEGVEIDF ELRCHRTTLK AYTTRPDTLF 250
    GATYLVIAPE HPMAEKLATA PQLLVVKEYI TKAKLKSDLE RTGLQKEKSG 300
    VFTGSYAINP ATGQPLPIWI SDFVLISYGT GAIMSVPAHD SRDWAFAKQY 350
    NLPIIEVIKS PHDVQEAVFE EKNSTCVNSA NDEISLNGLD FATAFERMAT 400
    WLESKKVGKR KVNYKLRDWI FSRQRYWGEP IPIKHYEDGT IRPETNLPLE 450
    LPAVEAYHPT STGESPLANI TEWLIGNDEH GAFRRETNTM PQWAGSCWYY 500
    LRFIDPHNHA QVVDGNNERY WMNVDLYIGG AEHAVLHLLY SRFWHKVLYD 550
    LGVVSTKEPF QKLFNQGMIL GEDNEKMSKS RGNVIPADHV LQRYGADAVR 600
    LYEMFLGPLE QVKPWNTNGI EGISRFLGKV WRFVYPEHSE AATQPSNEPL 650
    PDELLRRMHK TIKKVGDDTS SLKFNTAIAE MMVFVNELTK TGCNNREAIE 700
    TLLKLLAPYA PHMTEELWEA LGHTNSISHE PFPTFNPALV EENMAIIAVQ 750
    VNGKLRGTFT VPAKSPKEML LEEARKVESV AKFLEGKTIV KEIVVPDKLV 800
    NFAVK 805
    Length:805
    Mass (Da):92,007
    Last modified:November 22, 2005 - v1
    Checksum:iA0C78B83732AF54C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000108 Genomic DNA. Translation: ABB28940.1.
    RefSeqiYP_379983.1. NC_007514.1.

    Genome annotation databases

    EnsemblBacteriaiABB28940; ABB28940; Cag_1688.
    GeneIDi3746378.
    KEGGicch:Cag_1688.
    PATRICi21371119. VBIChlChl46571_1754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000108 Genomic DNA. Translation: ABB28940.1 .
    RefSeqi YP_379983.1. NC_007514.1.

    3D structure databases

    ProteinModelPortali Q3APY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340177.Cag_1688.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB28940 ; ABB28940 ; Cag_1688 .
    GeneIDi 3746378.
    KEGGi cch:Cag_1688.
    PATRICi 21371119. VBIChlChl46571_1754.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CCHL340177:GHBW-1704-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chlorobium chlorochromatii CaD3."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CaD3.

    Entry informationi

    Entry nameiSYL_CHLCH
    AccessioniPrimary (citable) accession number: Q3APY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3