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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCHL340177:G1G4Y-1833-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Cag_1688
OrganismiChlorobium chlorochromatii (strain CaD3)
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000002708 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093201 – 805Leucine--tRNA ligaseAdd BLAST805

Proteomic databases

PRIDEiQ3APY5

Interactioni

Protein-protein interaction databases

STRINGi340177.Cag_1688

Structurei

3D structure databases

ProteinModelPortaliQ3APY5
SMRiQ3APY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q3APY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFTSIEK KWQTRWQAEA TFATGTDHSK PKYYVLDMFP YPSGSGLHVG
60 70 80 90 100
HLEGYTASDI IARYKRSSGY NVLHPMGWDA FGLPAEQFAI KTGTHPRITT
110 120 130 140 150
EANVKNFKGT LQAMGFSYDW EREINTTDSG YFKWTQWIFL QLYDRGLAYM
160 170 180 190 200
SEVDVNWCEE LKTVLANEEV DEKLADGYTV VRRPLRQWVL KITAYAERLL
210 220 230 240 250
ADLEELDWPE NVKQMQRNWI GRSEGVEIDF ELRCHRTTLK AYTTRPDTLF
260 270 280 290 300
GATYLVIAPE HPMAEKLATA PQLLVVKEYI TKAKLKSDLE RTGLQKEKSG
310 320 330 340 350
VFTGSYAINP ATGQPLPIWI SDFVLISYGT GAIMSVPAHD SRDWAFAKQY
360 370 380 390 400
NLPIIEVIKS PHDVQEAVFE EKNSTCVNSA NDEISLNGLD FATAFERMAT
410 420 430 440 450
WLESKKVGKR KVNYKLRDWI FSRQRYWGEP IPIKHYEDGT IRPETNLPLE
460 470 480 490 500
LPAVEAYHPT STGESPLANI TEWLIGNDEH GAFRRETNTM PQWAGSCWYY
510 520 530 540 550
LRFIDPHNHA QVVDGNNERY WMNVDLYIGG AEHAVLHLLY SRFWHKVLYD
560 570 580 590 600
LGVVSTKEPF QKLFNQGMIL GEDNEKMSKS RGNVIPADHV LQRYGADAVR
610 620 630 640 650
LYEMFLGPLE QVKPWNTNGI EGISRFLGKV WRFVYPEHSE AATQPSNEPL
660 670 680 690 700
PDELLRRMHK TIKKVGDDTS SLKFNTAIAE MMVFVNELTK TGCNNREAIE
710 720 730 740 750
TLLKLLAPYA PHMTEELWEA LGHTNSISHE PFPTFNPALV EENMAIIAVQ
760 770 780 790 800
VNGKLRGTFT VPAKSPKEML LEEARKVESV AKFLEGKTIV KEIVVPDKLV

NFAVK
Length:805
Mass (Da):92,007
Last modified:November 22, 2005 - v1
Checksum:iA0C78B83732AF54C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA Translation: ABB28940.1
RefSeqiWP_011362702.1, NC_007514.1

Genome annotation databases

EnsemblBacteriaiABB28940; ABB28940; Cag_1688
KEGGicch:Cag_1688

Similar proteinsi

Entry informationi

Entry nameiSYL_CHLCH
AccessioniPrimary (citable) accession number: Q3APY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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