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Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).UniRule annotationSAAS annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Isochorismate synthase MenF (menF)
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Proton donorUniRule annotation1
Metal bindingi181MagnesiumUniRule annotation1
Metal bindingi207MagnesiumUniRule annotation1
Metal bindingi230MagnesiumUniRule annotation1
Active sitei254Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processMenaquinone biosynthesisUniRule annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthaseUniRule annotationSAAS annotation (EC:4.2.1.113UniRule annotation)
Short name:
OSB synthaseUniRule annotation
Short name:
OSBSUniRule annotation
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthaseUniRule annotation
o-succinylbenzoic acid synthaseUniRule annotation
Gene namesi
Name:menCUniRule annotation
Ordered Locus Names:Cag_1718Imported
OrganismiChlorobium chlorochromatii (strain CaD3)Imported
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000002708 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi340177.Cag_1718.

Structurei

3D structure databases

ProteinModelPortaliQ3APV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 226MR_MLEInterPro annotationAdd BLAST96

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108HXM. Bacteria.
COG1441. LUCA.
HOGENOMiHOG000153853.
KOiK02549.
OMAiYEANRDG.
OrthoDBiPOG091H04PO.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00470. MenC_1. 1 hit.
InterProiView protein in InterPro
IPR036849. Enolase-like_C.
IPR029017. Enolase-like_N.
IPR029065. Enolase_C-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR010196. OSB_synthase_MenC1.
PfamiView protein in Pfam
PF13378. MR_MLE_C. 1 hit.
SMARTiView protein in SMART
SM00922. MR_MLE. 1 hit.
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiView protein in PROSITE
PS00909. MR_MLE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3APV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELELSLYRY AIPFTEPITV KQQRLVMRDG LVLALTSATE AVTAFGEIAP
60 70 80 90 100
LFGLHSETLE QAEAQLVTLF ATPHTTLARI MEAQFYPSVR TGLEMAIHNF
110 120 130 140 150
TAARSGALPR FGTTPHNAEQ VPVNALLFGA SNEVVERAER LFTAGYRTFK
160 170 180 190 200
LKVNAANSAN AIASIQALHS RFGNAIALRL DANQSFTLND AIAFGKALPD
210 220 230 240 250
GSIAYIEEPL QNAERIGDFY AATAIPAALD ETLWQNPALL DIIPTKALAA
260 270 280 290 300
LVLKPNRLGG ITVAEKFARY AAERGLLAVV SSAFESGISL GFYAWLAASC
310 320 330 340 350
NAEPAACGLD TSRYLAFDVL TTPFPTNTPL LDAAQCYRNS LQVNLATLKP
360
CAMPQSFRIL MEN
Length:363
Mass (Da):39,230
Last modified:November 22, 2005 - v1
Checksum:iAB55F00C1571540C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA. Translation: ABB28969.1.
RefSeqiWP_011362731.1. NC_007514.1.

Genome annotation databases

EnsemblBacteriaiABB28969; ABB28969; Cag_1718.
KEGGicch:Cag_1718.

Similar proteinsi

Entry informationi

Entry nameiQ3APV6_CHLCH
AccessioniPrimary (citable) accession number: Q3APV6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported