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Protein

Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-HAMAP
  2. aminopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminopeptidaseImported, Hydrolase, LyaseUniRule annotation, Protease

Keywords - Biological processi

Menaquinone biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciCCHL340177:GHBW-1735-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00900.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:Cag_1720Imported
OrganismiChlorobium chlorochromatii (strain CaD3)Imported
Taxonomic identifieri340177 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000002708: Chromosome

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi340177.Cag_1720.

Structurei

3D structure databases

ProteinModelPortaliQ3APV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
KOiK08680.
OMAiNCGHTIN.
OrthoDBiEOG689HPM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3APV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIMQPPLHIE IIGNKALPKI VFLHGFLGSG RDWLPLAEML TSHYCCVLVD
60 70 80 90 100
LPGHGSATLS ASDEHHAYFT ATVEALATVI QPISPEPCRL VGYSMGGRIA
110 120 130 140 150
LALMLTHPEL FHQAVIVSAS PGLPTEEERA KRRAGDEGIA RKIERNFPDF
160 170 180 190 200
LEAWYQQPLF STLKNHPLFQ EIERKRAINN SESLAAALRL LGTGQQPSFW
210 220 230 240 250
DALSKCAVPT LFIAGEKDER YVAIARQMVK LAPHATLSIV PNCGHTLHIE
260
NKESFVEQLH TFFNQ
Length:265
Mass (Da):29,422
Last modified:November 22, 2005 - v1
Checksum:iD36006E75EA886E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA. Translation: ABB28971.1.
RefSeqiWP_011362733.1. NC_007514.1.
YP_380014.1. NC_007514.1.

Genome annotation databases

EnsemblBacteriaiABB28971; ABB28971; Cag_1720.
GeneIDi3746986.
KEGGicch:Cag_1720.
PATRICi21371192. VBIChlChl46571_1790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000108 Genomic DNA. Translation: ABB28971.1.
RefSeqiWP_011362733.1. NC_007514.1.
YP_380014.1. NC_007514.1.

3D structure databases

ProteinModelPortaliQ3APV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi340177.Cag_1720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB28971; ABB28971; Cag_1720.
GeneIDi3746986.
KEGGicch:Cag_1720.
PATRICi21371192. VBIChlChl46571_1790.

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
KOiK08680.
OMAiNCGHTIN.
OrthoDBiEOG689HPM.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00900.
BioCyciCCHL340177:GHBW-1735-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Chlorobium chlorochromatii CaD3."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CaD3Imported.

Entry informationi

Entry nameiQ3APV4_CHLCH
AccessioniPrimary (citable) accession number: Q3APV4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: February 4, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.