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Q3APU1

- GCSPA_CHLCH

UniProt

Q3APU1 - GCSPA_CHLCH

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Chlorobium chlorochromatii (strain CaD3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciCCHL340177:GHBW-1748-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Cag_1733
    OrganismiChlorobium chlorochromatii (strain CaD3)
    Taxonomic identifieri340177 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
    ProteomesiUP000002708: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045641Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi340177.Cag_1733.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3APU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiFFHEAVL.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3APU1-1 [UniParc]FASTAAdd to Basket

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    MPFIATTESE RTEMLQAIGV NSFDELIADI PYSVRLQRAL ELLPSLDEPQ    50
    VRRLLERMAA SNRCTAEYVS FLGGGAYDHF IPSAIKTIIS RSEFYTAYTP 100
    YQAEVSQGTL QAIYEYQSLM CRLYGMDVAN ASMYDGATAL AEAVLMAMNV 150
    TGRDQVVVAG KLHPHTTAVL KTYLEASGHQ AIIQNALVDG RSDIAALKAL 200
    VNQQVAAVVV QQPNFYGCLE EVEAIGAITH EQGAIFVVSA DPLSLGVLAA 250
    PGSYGADIAV GEGQPLGSSQ SFGGPYLGIF TVKQQLVRKI PGRLVGMTKD 300
    RDGEDGFILT LQTREQHIRR EKATSNICSN QALNALQAAV YLSLLGKQGL 350
    QQVAAQSAQK AHYLANAIAA LPGFSLKFTA PFFREFVVET PMPAAHLIEQ 400
    MVEQRMFAGY DLATHGESGL LIAVTEQRTK EELDAFVAAL SALKA 445
    Length:445
    Mass (Da):48,071
    Last modified:November 22, 2005 - v1
    Checksum:i62AA94626B933532
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000108 Genomic DNA. Translation: ABB28984.1.
    RefSeqiWP_011362746.1. NC_007514.1.
    YP_380027.1. NC_007514.1.

    Genome annotation databases

    EnsemblBacteriaiABB28984; ABB28984; Cag_1733.
    GeneIDi3746516.
    KEGGicch:Cag_1733.
    PATRICi21371222. VBIChlChl46571_1805.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000108 Genomic DNA. Translation: ABB28984.1 .
    RefSeqi WP_011362746.1. NC_007514.1.
    YP_380027.1. NC_007514.1.

    3D structure databases

    ProteinModelPortali Q3APU1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340177.Cag_1733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB28984 ; ABB28984 ; Cag_1733 .
    GeneIDi 3746516.
    KEGGi cch:Cag_1733.
    PATRICi 21371222. VBIChlChl46571_1805.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi FFHEAVL.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci CCHL340177:GHBW-1748-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chlorobium chlorochromatii CaD3."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CaD3.

    Entry informationi

    Entry nameiGCSPA_CHLCH
    AccessioniPrimary (citable) accession number: Q3APU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3