Reviewed, UniProtKB/Swiss-Prot Q3APL9 (DAPB_CHLCH)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Cag_1805

Organism

Chlorobium chlorochromatii (strain CaD3) [Complete proteome] [HAMAP]

Taxonomic identifier

340177 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Dihydrodipicolinate reductase		PRO_0000228338

Sequences

	Sequence		Length	Mass (Da)
	Q3APL9-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 550D36B4E9B1706D	FASTA	249	26,844
	10 20 30 40 50 60 MKFTLIGNGR MGQQVAHIIN NSSAHSIAAI LDVDATITPE VFHGSDAIID FTVRHAFLEN 70 80 90 100 110 120 LPAMVASGVP IVVGTTGWDD VQADVRQQIA AANTSLLYSA NFSLGVNIFM RIVREAARMI 130 140 150 160 170 180 EPFSHFDIAL TEQHHTGKAD FPSGTALRTA QMVLAANSRK TSIVRELADG NKLTPNELHV 190 200 210 220 230 240 ASLRLGTIFG KHSAFIDSET DDIEISHTAK SRSGFAAGAV EAAAWLALRH TTAPGFYTMD DFLDEKLGK

References

[1]

"Complete sequence of Chlorobium chlorochromatii CaD3." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000108 Genomic DNA. Translation: ABB29056.1.
RefSeq	YP_380099.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3746920.
GenomeReviews	Gene locus Cag_1805 in contig CP000108_GR.
KEGG	cch:Cag_1805.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3APL9.
Enzyme and pathway databases
BioCyc	CCHL340177:CAG_1805-MON.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_CHLCH

Accession

Primary (citable) accession number: Q3APL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 22, 2005
Last modified:	November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)