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Protein

Thiazole synthase

Gene

thiG

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur-carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei111Schiff-base intermediate with DXPUniRule annotation1
Binding sitei172DXP; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processThiamine biosynthesis
LigandSchiff base

Enzyme and pathway databases

BioCyciSSP110662:G1G50-56-MONOMER
UniPathwayiUPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiazole synthaseUniRule annotation (EC:2.8.1.10UniRule annotation)
Gene namesi
Name:thiGUniRule annotation
Ordered Locus Names:Syncc9605_0054
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002363691 – 272Thiazole synthaseAdd BLAST272

Interactioni

Subunit structurei

Homotetramer. Forms heterodimers with either ThiH or ThiS.UniRule annotation

Protein-protein interaction databases

STRINGi110662.Syncc9605_0054

Structurei

3D structure databases

ProteinModelPortaliQ3ANJ9
SMRiQ3ANJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 199DXP bindingUniRule annotation2
Regioni220 – 221DXP bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ThiG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CA8 Bacteria
COG2022 LUCA
HOGENOMiHOG000248049
KOiK03149
OMAiAQYPSPA
OrthoDBiPOG091H01K9

Family and domain databases

CDDicd04728 ThiG, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00443 ThiG, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033983 Thiazole_synthase_ThiG
IPR008867 ThiG
PANTHERiPTHR34266 PTHR34266, 1 hit
PfamiView protein in Pfam
PF05690 ThiG, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ANJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPSPNSDP LTIGGRQFNS RLFTGTGKYP SMTSMQQSIE RSGCDMVTVA
60 70 80 90 100
VRRVQTVAAG HEGLMEAIDW QRIWMLPNTA GCTNAEEAVR VARLGRELAK
110 120 130 140 150
LAGQEDNTFV KLEVIPDARH LLPDPIGTLN AAEQLVKEGF TVLPYINADP
160 170 180 190 200
LLAKRLEEVG CATVMPLGSP IGSGQGLNNA ANIGLIIENA GVPVVVDAGI
210 220 230 240 250
GVPSEAAQAL EMGADAVLVN SAIALAGDPA AMASAMSQAV MAGRTAHLSG
260 270
RLPRRDQASA SSPTTGLVQS PQ
Length:272
Mass (Da):28,319
Last modified:November 22, 2005 - v1
Checksum:iD093D2224C16C263
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB33833.1
RefSeqiWP_011363095.1, NC_007516.1

Genome annotation databases

EnsemblBacteriaiABB33833; ABB33833; Syncc9605_0054
KEGGisyd:Syncc9605_0054

Similar proteinsi

Entry informationi

Entry nameiTHIG_SYNSC
AccessioniPrimary (citable) accession number: Q3ANJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 22, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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