Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase

Gene

katG

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Transition state stabilizerUniRule annotation
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi259 – 2591Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSSP110662:GJ7R-185-MONOMER.

Protein family/group databases

PeroxiBasei2714. SspCP01_CC9605.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Syncc9605_0181
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Catalase-peroxidasePRO_0000354943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki95 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ3AN75.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi110662.Syncc9605_0181.

Structurei

3D structure databases

ProteinModelPortaliQ3AN75.
SMRiQ3AN75. Positions 21-728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AN75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLKCPFSG HTGAVTASAH TGNRQWWPIQ IDLGLLHQHH PASNPLGDTF
60 70 80 90 100
DYPAAFAGLD LEALKADLAA LMTDSQDWWP ADWGHYGGLF IRMAWHSAGT
110 120 130 140 150
YRGADGRGGA GHGNQRFAPL NSWPDNTNLD KARRLLWPLK RKYGNAISWA
160 170 180 190 200
DLIILSGNVA LESMGFRTFG FAGGRTDIWQ PEEDVFWGKE TEWLSDERHT
210 220 230 240 250
TEGALDQPLA AVEMGLVYVN PEGPHGHPDP VASGPDVRDT FARMGMTMEE
260 270 280 290 300
TVALVAGGHT FGKCHGAAPV SQLEAEPEGA ELHQQGLGWH NRFESGKGEH
310 320 330 340 350
TITSGIEGAW KPHPTRWDQG YFEMMFTYEW ELTKSPAGAW QWVAKDVKPE
360 370 380 390 400
HMIPDAHVPG RASAPIMTTA DLSLRHDPLM EPVARRFHQD QDAFADAFAR
410 420 430 440 450
AWFKLTHRDL GPRALYLGAD VPEEIQIWQD PVPALDHPLI GAVEIKALKQ
460 470 480 490 500
KLLATGCSVG ALVATAWGAA STFRGSDRRG GANGGRIRFQ PQNTWEVNDP
510 520 530 540 550
EQLRSVLQTL ETVQQQFNAE ATGGQRVSMA DLIVLAGSAA VEQAAAAGGH
560 570 580 590 600
SVTVPFLPGR MDASADQTDT ASFNLLKPIA DGFRNWQRSG LPLRAEECLV
610 620 630 640 650
DRAQQLGLSA PEMTVLLAGL RVLGANNGGN RQGVLTDRVG VLSNDFCVNL
660 670 680 690 700
LDMSIRWSPT SEAMEGYIGR DAQGSERWTA SRADLVFGSN SQLRAIVEVY
710 720
AQDDGASRFV SDFVQAWVKV MNLDRFDVR
Length:729
Mass (Da):79,745
Last modified:November 22, 2005 - v1
Checksum:iE5807A9FB6F6C145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA. Translation: ABB33957.1.
RefSeqiWP_011363215.1. NC_007516.1.

Genome annotation databases

EnsemblBacteriaiABB33957; ABB33957; Syncc9605_0181.
KEGGisyd:Syncc9605_0181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA. Translation: ABB33957.1.
RefSeqiWP_011363215.1. NC_007516.1.

3D structure databases

ProteinModelPortaliQ3AN75.
SMRiQ3AN75. Positions 21-728.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi110662.Syncc9605_0181.

Protein family/group databases

PeroxiBasei2714. SspCP01_CC9605.

Proteomic databases

PRIDEiQ3AN75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB33957; ABB33957; Syncc9605_0181.
KEGGisyd:Syncc9605_0181.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciSSP110662:GJ7R-185-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Synechococcus sp. CC9605."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9605.

Entry informationi

Entry nameiKATG_SYNSC
AccessioniPrimary (citable) accession number: Q3AN75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 22, 2005
Last modified: December 9, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.