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Protein

Catalase-peroxidase

Gene

katG

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei92Transition state stabilizerUniRule annotation1
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi259Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSSP110662:G1G50-184-MONOMER

Protein family/group databases

PeroxiBasei2714 SspCP01_CC9605

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Syncc9605_0181
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549431 – 729Catalase-peroxidaseAdd BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki95 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ3AN75

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi110662.Syncc9605_0181

Structurei

3D structure databases

ProteinModelPortaliQ3AN75
SMRiQ3AN75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 2 hits

Sequencei

Sequence statusi: Complete.

Q3AN75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLKCPFSG HTGAVTASAH TGNRQWWPIQ IDLGLLHQHH PASNPLGDTF
60 70 80 90 100
DYPAAFAGLD LEALKADLAA LMTDSQDWWP ADWGHYGGLF IRMAWHSAGT
110 120 130 140 150
YRGADGRGGA GHGNQRFAPL NSWPDNTNLD KARRLLWPLK RKYGNAISWA
160 170 180 190 200
DLIILSGNVA LESMGFRTFG FAGGRTDIWQ PEEDVFWGKE TEWLSDERHT
210 220 230 240 250
TEGALDQPLA AVEMGLVYVN PEGPHGHPDP VASGPDVRDT FARMGMTMEE
260 270 280 290 300
TVALVAGGHT FGKCHGAAPV SQLEAEPEGA ELHQQGLGWH NRFESGKGEH
310 320 330 340 350
TITSGIEGAW KPHPTRWDQG YFEMMFTYEW ELTKSPAGAW QWVAKDVKPE
360 370 380 390 400
HMIPDAHVPG RASAPIMTTA DLSLRHDPLM EPVARRFHQD QDAFADAFAR
410 420 430 440 450
AWFKLTHRDL GPRALYLGAD VPEEIQIWQD PVPALDHPLI GAVEIKALKQ
460 470 480 490 500
KLLATGCSVG ALVATAWGAA STFRGSDRRG GANGGRIRFQ PQNTWEVNDP
510 520 530 540 550
EQLRSVLQTL ETVQQQFNAE ATGGQRVSMA DLIVLAGSAA VEQAAAAGGH
560 570 580 590 600
SVTVPFLPGR MDASADQTDT ASFNLLKPIA DGFRNWQRSG LPLRAEECLV
610 620 630 640 650
DRAQQLGLSA PEMTVLLAGL RVLGANNGGN RQGVLTDRVG VLSNDFCVNL
660 670 680 690 700
LDMSIRWSPT SEAMEGYIGR DAQGSERWTA SRADLVFGSN SQLRAIVEVY
710 720
AQDDGASRFV SDFVQAWVKV MNLDRFDVR
Length:729
Mass (Da):79,745
Last modified:November 22, 2005 - v1
Checksum:iE5807A9FB6F6C145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB33957.1
RefSeqiWP_011363215.1, NC_007516.1

Genome annotation databases

EnsemblBacteriaiABB33957; ABB33957; Syncc9605_0181
KEGGisyd:Syncc9605_0181

Similar proteinsi

Entry informationi

Entry nameiKATG_SYNSC
AccessioniPrimary (citable) accession number: Q3AN75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 22, 2005
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health