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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15SubstrateUniRule annotation1
Binding sitei42Substrate; via amide nitrogenUniRule annotation1
Binding sitei72Pyridoxal phosphateUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132Pyridoxal phosphateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei187Pyridoxal phosphateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei218Pyridoxal phosphateUniRule annotation1
Binding sitei257Pyridoxal phosphateUniRule annotation1
Binding sitei292Pyridoxal phosphateUniRule annotation1
Binding sitei292SubstrateUniRule annotation1
Binding sitei388SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:Syncc9605_0311
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003125461 – 408LL-diaminopimelate aminotransferaseAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ3AMU5.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi110662.Syncc9605_0311.

Structurei

3D structure databases

ProteinModelPortaliQ3AMU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 109Pyridoxal phosphate bindingUniRule annotation2
Regioni246 – 248Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QSS. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223061.
KOiK10206.
OMAiRCAFTVV.
OrthoDBiPOG091H0235.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AMU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQVNGNYLK LKAGYLFPEI GRRVKAFSSA NPDAALIRLG IGDVTEPLPL
60 70 80 90 100
ACREAMKTAI DAMGTAEGFH GYGPEQGYGW LREAIAKNDF QARGCDISAE
110 120 130 140 150
EIFVSDGSKC DSSNILDILG EGNKVAVTDP VYPVYVDSNV MAGRTGEAGE
160 170 180 190 200
IGRYAGLTYL PISADNGFAA LIPSEPVDLI YLCFPNNPTG AVATREQLQA
210 220 230 240 250
WVNYARANGA LILFDAAYEA FIQDPELPRS IFEIEGARDC AIEFRSFSKN
260 270 280 290 300
AGFTGTRCAF TVVPKGLKGK AANGEAVELW GLWNRRQSTK FNGVSYIIQR
310 320 330 340 350
GAEAVYSEAG QAEVKALVSF YMENAAIIRR ELTAAGLTVY GGEHAPYVWI
360 370 380 390 400
KTPEGMDSWG FFDHLLNKAN VVGTPGSGFG AAGECYFRLS AFNSRANVDE

AMARIKAL
Length:408
Mass (Da):44,036
Last modified:November 22, 2005 - v1
Checksum:i0D71757E6B2AC677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA. Translation: ABB34087.1.
RefSeqiWP_011363338.1. NC_007516.1.

Genome annotation databases

EnsemblBacteriaiABB34087; ABB34087; Syncc9605_0311.
KEGGisyd:Syncc9605_0311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA. Translation: ABB34087.1.
RefSeqiWP_011363338.1. NC_007516.1.

3D structure databases

ProteinModelPortaliQ3AMU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi110662.Syncc9605_0311.

Proteomic databases

PRIDEiQ3AMU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB34087; ABB34087; Syncc9605_0311.
KEGGisyd:Syncc9605_0311.

Phylogenomic databases

eggNOGiENOG4107QSS. Bacteria.
COG0436. LUCA.
HOGENOMiHOG000223061.
KOiK10206.
OMAiRCAFTVV.
OrthoDBiPOG091H0235.

Enzyme and pathway databases

UniPathwayiUPA00034; UER00466.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_SYNSC
AccessioniPrimary (citable) accession number: Q3AMU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.