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Q3AMU5

- DAPAT_SYNSC

UniProt

Q3AMU5 - DAPAT_SYNSC

Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421Substrate; via amide nitrogenUniRule annotation
    Binding sitei72 – 721Pyridoxal phosphate; shared with dimeric partnerUniRule annotation
    Binding sitei75 – 751Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Binding sitei187 – 1871Pyridoxal phosphateUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation
    Binding sitei215 – 2151Pyridoxal phosphateUniRule annotation
    Binding sitei218 – 2181Pyridoxal phosphateUniRule annotation
    Binding sitei246 – 2461Pyridoxal phosphateUniRule annotation
    Binding sitei248 – 2481Pyridoxal phosphateUniRule annotation
    Binding sitei257 – 2571Pyridoxal phosphateUniRule annotation
    Binding sitei292 – 2921Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei388 – 3881SubstrateUniRule annotation

    GO - Molecular functioni

    1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSSP110662:GJ7R-319-MONOMER.
    UniPathwayiUPA00034; UER00466.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
    Short name:
    DAP-ATUniRule annotation
    Short name:
    DAP-aminotransferaseUniRule annotation
    Short name:
    LL-DAP-aminotransferaseUniRule annotation
    Gene namesi
    Name:dapLUniRule annotation
    Ordered Locus Names:Syncc9605_0311
    OrganismiSynechococcus sp. (strain CC9605)
    Taxonomic identifieri110662 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002711: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408LL-diaminopimelate aminotransferasePRO_0000312546Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei249 – 2491N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ3AMU5.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi110662.Syncc9605_0311.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3AMU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223061.
    KOiK10206.
    OMAiHAPYVWL.
    OrthoDBiEOG6XWV2X.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01642. DapL_aminotrans_1.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3AMU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQVNGNYLK LKAGYLFPEI GRRVKAFSSA NPDAALIRLG IGDVTEPLPL    50
    ACREAMKTAI DAMGTAEGFH GYGPEQGYGW LREAIAKNDF QARGCDISAE 100
    EIFVSDGSKC DSSNILDILG EGNKVAVTDP VYPVYVDSNV MAGRTGEAGE 150
    IGRYAGLTYL PISADNGFAA LIPSEPVDLI YLCFPNNPTG AVATREQLQA 200
    WVNYARANGA LILFDAAYEA FIQDPELPRS IFEIEGARDC AIEFRSFSKN 250
    AGFTGTRCAF TVVPKGLKGK AANGEAVELW GLWNRRQSTK FNGVSYIIQR 300
    GAEAVYSEAG QAEVKALVSF YMENAAIIRR ELTAAGLTVY GGEHAPYVWI 350
    KTPEGMDSWG FFDHLLNKAN VVGTPGSGFG AAGECYFRLS AFNSRANVDE 400
    AMARIKAL 408
    Length:408
    Mass (Da):44,036
    Last modified:November 22, 2005 - v1
    Checksum:i0D71757E6B2AC677
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000110 Genomic DNA. Translation: ABB34087.1.
    RefSeqiWP_011363338.1. NC_007516.1.
    YP_380642.1. NC_007516.1.

    Genome annotation databases

    EnsemblBacteriaiABB34087; ABB34087; Syncc9605_0311.
    GeneIDi3737545.
    KEGGisyd:Syncc9605_0311.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000110 Genomic DNA. Translation: ABB34087.1 .
    RefSeqi WP_011363338.1. NC_007516.1.
    YP_380642.1. NC_007516.1.

    3D structure databases

    ProteinModelPortali Q3AMU5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 110662.Syncc9605_0311.

    Proteomic databases

    PRIDEi Q3AMU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB34087 ; ABB34087 ; Syncc9605_0311 .
    GeneIDi 3737545.
    KEGGi syd:Syncc9605_0311.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223061.
    KOi K10206.
    OMAi HAPYVWL.
    OrthoDBi EOG6XWV2X.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00466 .
    BioCyci SSP110662:GJ7R-319-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01642. DapL_aminotrans_1.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Synechococcus sp. CC9605."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9605.

    Entry informationi

    Entry nameiDAPAT_SYNSC
    AccessioniPrimary (citable) accession number: Q3AMU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3