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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (Syncc9605_2666)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei17Transition state stabilizerUniRule annotation1
Active sitei22Proton acceptorUniRule annotation1
Binding sitei73SubstrateUniRule annotation1
Binding sitei79SubstrateUniRule annotation1
Binding sitei86SubstrateUniRule annotation1
Active sitei99Proton donorUniRule annotation1
Binding sitei110SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciSSP110662:G1G50-523-MONOMER
UniPathwayiUPA00053; UER00086

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type II DHQaseUniRule annotation
Gene namesi
Name:aroQUniRule annotation
Ordered Locus Names:Syncc9605_0502
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000235261 – 1463-dehydroquinate dehydrataseAdd BLAST146

Interactioni

Subunit structurei

Homododecamer.UniRule annotation

Protein-protein interaction databases

STRINGi110662.Syncc9605_0502

Structurei

3D structure databases

ProteinModelPortaliQ3AMA6
SMRiQ3AMA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 101Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z38 Bacteria
COG0757 LUCA
HOGENOMiHOG000217278
KOiK03786
OMAiAYTHYSY
OrthoDBiPOG091H03XJ

Family and domain databases

CDDicd00466 DHQase_II, 1 hit
Gene3Di3.40.50.9100, 1 hit
HAMAPiMF_00169 AroQ, 1 hit
InterProiView protein in InterPro
IPR001874 DHquinase_II
IPR018509 DHquinase_II_CS
IPR036441 DHquinase_II_sf
PANTHERiPTHR21272 PTHR21272, 1 hit
PfamiView protein in Pfam
PF01220 DHquinase_II, 1 hit
PIRSFiPIRSF001399 DHquinase_II, 1 hit
SUPFAMiSSF52304 SSF52304, 1 hit
TIGRFAMsiTIGR01088 aroQ, 1 hit
PROSITEiView protein in PROSITE
PS01029 DEHYDROQUINASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AMA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVLLLNGPN LNLLGQREPG IYGHSSLADI EAALTREAEQ ESVQLDCFQS
60 70 80 90 100
NFEGALVDRI HQAMGRCDGI LINAGAYTHT SIAIRDALAG VAIPYVEVHL
110 120 130 140
SNTHARENFR HHSFLAERAV GVICGFGPAS YSFALNGLLS HLRRNA
Length:146
Mass (Da):15,860
Last modified:November 22, 2005 - v1
Checksum:iB4563170D27A552A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB34276.1
RefSeqiWP_011363508.1, NC_007516.1

Genome annotation databases

EnsemblBacteriaiABB34276; ABB34276; Syncc9605_0502
KEGGisyd:Syncc9605_0502

Similar proteinsi

Entry informationi

Entry nameiAROQ_SYNSC
AccessioniPrimary (citable) accession number: Q3AMA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health