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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi495MagnesiumUniRule annotation1
Metal bindingi501MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Syncc9605_0570
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003298971 – 721Polyribonucleotide nucleotidyltransferaseAdd BLAST721

Interactioni

Protein-protein interaction databases

STRINGi110662.Syncc9605_0570.

Structurei

3D structure databases

ProteinModelPortaliQ3AM38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini562 – 621KHUniRule annotationAdd BLAST60
Domaini631 – 699S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AM38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGQTQSISF DGREIRLTTG RFAPQAGGSV LVECGDTAVL VTATRSGGRE
60 70 80 90 100
GIDFLPLICD YEERLYAAGR IPGSYMRRES RPPERATLTA RLIDRPMRPL
110 120 130 140 150
FPSWLRDDLQ VVATCLSLDE RVPADVLAVT GASIATLLAG IPFNGPMAAV
160 170 180 190 200
RVGLLGDDFV LNPSYREIER GDLDLVVAGT PDGVVMVEAG ANQLPEQDVI
210 220 230 240 250
EAIDFGYEAI CELIKAQEQL LKDLGITQVK PEKPDEDSTV PAYLEKQCSK
260 270 280 290 300
AISAVLSKFD QSKDERDTAL ETVKGEVSET IAGLKEDHAV RQALASSPKL
310 320 330 340 350
LGNSFKALTK KLMRQQILKD GKRVDGRGLD EVRQISAMAG VLPRRVHGSG
360 370 380 390 400
LFQRGLTQVL STATLGTPSD AQEMDDLHPN TEKLYLHHYN FPPYSVGETR
410 420 430 440 450
PMRSPGRREI GHGALAERAI LPVLPEKDTF PYVVRVVSEV LSSNGSTSMG
460 470 480 490 500
SVCGSTLSLM DAGVPLKAPV SGAAMGLIKE GDEVRILTDI QGIEDFLGDM
510 520 530 540 550
DFKVAGSEKG ITALQMDMKI TGLSVKTVAE AVNQARPARL HILEKMLEAI
560 570 580 590 600
DTPRDNLSPH APRLLSFRID PELIGTVIGP GGRTIKGITE RTNTKIDIED
610 620 630 640 650
GGIVTIASHD GAAAEEAQKI IEGLTRKVNE GEVFSGSITR IIPIGAFVEI
660 670 680 690 700
LPGKEGMIHI SQLSEARVEK VEDVVKVGDE VTVRVREIDN RGRINLTLRG
710 720
VPQAGDAADV EPQPTPVAPL S
Length:721
Mass (Da):77,724
Last modified:November 22, 2005 - v1
Checksum:iF8B5E3B55DFC5B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA. Translation: ABB34344.1.
RefSeqiWP_011363575.1. NC_007516.1.

Genome annotation databases

EnsemblBacteriaiABB34344; ABB34344; Syncc9605_0570.
KEGGisyd:Syncc9605_0570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA. Translation: ABB34344.1.
RefSeqiWP_011363575.1. NC_007516.1.

3D structure databases

ProteinModelPortaliQ3AM38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi110662.Syncc9605_0570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB34344; ABB34344; Syncc9605_0570.
KEGGisyd:Syncc9605_0570.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_SYNSC
AccessioniPrimary (citable) accession number: Q3AM38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.