Q3ALX6 (KGUA_SYNSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Syncc9605_0632

Organism

Synechococcus sp. (strain CC9605) [Complete proteome] [HAMAP]

Taxonomic identifier

110662 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266421
Regions
	Domain	5 – 183	179	Guanylate kinase-like
	Nucleotide binding	12 – 19	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ALX6 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: CEEA89A225860217	FASTA	185	20,507
	10 20 30 40 50 60 MSTSGKLTLI TGPSGVGKGT LVNQLLERHP QIWLSVSATT RSPRQGEQDG INYFFHSRAG 70 80 90 100 110 120 FEALVEQGGF LEWAEFAGNC YGTPRGPVEQ QMAAGRPVLL EIELEGARQV RRSFPDGFQI 130 140 150 160 170 180 FLAPPSFDEL ERRIRGRGTD SEDAIQRRLT RAREELEAQQ EFDAVVINDD LESALNQVET LMGLG

References

[1]

"Complete sequence of Synechococcus sp. CC9605." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9605.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000110 Genomic DNA. Translation: ABB34406.1.
RefSeq	YP_380961.1. NC_007516.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZNW based on UniProtKB P0A5I4.
ProteinModelPortal	Q3ALX6.
ModBase	Search...
Protein-protein interaction databases
STRING	110662.Syncc9605_0632.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB34406; ABB34406; Syncc9605_0632.
GeneID	3735692.
KEGG	syd:Syncc9605_0632.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037640.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_SYNSC

Accession

Primary (citable) accession number: Q3ALX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program