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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP110662:G1G50-673-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Syncc9605_0641
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002374091 – 477Glutamate--tRNA ligaseAdd BLAST477

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi110662.Syncc9605_0641

Structurei

3D structure databases

ProteinModelPortaliQ3ALW7
SMRiQ3ALW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi247 – 251"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ALW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVRLAPSP TGTLHIGTAR TAVFNWLYAK HEQGAFVLRI EDTDKERSKP
60 70 80 90 100
EYTQNILEGL QWLGINWDEE PVIQSERVAQ HREAIQTLLD RGLAYRCYAS
110 120 130 140 150
ETELTAMRDA QKAANQAPRY DNRHRTLTPE QEQAFQTEGR EAVIRFRIDD
160 170 180 190 200
AAEIRWNDLV RGAMSWRGSD LGGDMVIARR APADQIGDPL YNLVVVVDDA
210 220 230 240 250
SMEITHVIRG EDHIANTAKQ LLLYEALGLP LPTFAHAPLI LNAEGRKLSK
260 270 280 290 300
RDGVTSINDF RAMGYTPDAI ANYMTLLGWS VPEGMEEQFS LCEAAAVFGF
310 320 330 340 350
DRVNKAGARF DWDKLNWLNA QVLHGWTADH LLEELTPLWA ERGWTPPSEK
360 370 380 390 400
SWCLDLCALL GPSLTLLKDG VDQAEPFFDR PDLQEDALKQ LGIEGAKAAM
410 420 430 440 450
ADLLQRLENN PWDGSDVDQA KAWLGDAAKA ADVKKGVVMK SLRAALLGRL
460 470
QGPDLITTWS LLARIGEDLP RLRRCLG
Length:477
Mass (Da):53,356
Last modified:November 22, 2005 - v1
Checksum:i812AF3B9461F1427
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB34415.1
RefSeqiWP_011363643.1, NC_007516.1

Genome annotation databases

EnsemblBacteriaiABB34415; ABB34415; Syncc9605_0641
KEGGisyd:Syncc9605_0641

Similar proteinsi

Entry informationi

Entry nameiSYE_SYNSC
AccessioniPrimary (citable) accession number: Q3ALW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 22, 2005
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health