Q3AL08 (GLO2_SYNSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hydroxyacylglutathione hydrolase
EC=3.1.2.6

Alternative name(s):
Glyoxalase II
Short name=Glx II

Gene names

Name:	gloB
Ordered Locus Names:	Syncc9605_0966

Organism

Synechococcus sp. (strain CC9605) [Complete proteome] [HAMAP]

Taxonomic identifier

110662 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374
Catalytic activity	S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374
Pathway	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374
Subunit structure	Monomer By similarity. HAMAP MF_01374
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Hydroxyacylglutathione hydrolase HAMAP MF_01374		PRO_0000309714
Sites
	Metal binding	54	1	Zinc 1 By similarity
	Metal binding	56	1	Zinc 1 By similarity
	Metal binding	58	1	Zinc 2 By similarity
	Metal binding	59	1	Zinc 2 By similarity
	Metal binding	113	1	Zinc 1 By similarity
	Metal binding	138	1	Zinc 1 By similarity
	Metal binding	138	1	Zinc 2 By similarity
	Metal binding	176	1	Zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3AL08 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: BEC8FA53AD29B889	FASTA	249	27,678
	10 20 30 40 50 60 MHSSLHALPV LQDNVIWIWV RGAEAVVIDP AVAPPVRAWL EKRQLSLAAV LQTHHHADHI 70 80 90 100 110 120 GGTPELLQRW PEAEVIASAD DRERIPFQTM PVRGGDHVTV LGETVEVMDV AAHTRAHIAF 130 140 150 160 170 180 FLPNPKGAEI RPLLFCGDTL FSGGCGRLFE GSAEQMHQAL QKLAELPEAT QVCCAHEYTE 190 200 210 220 230 240 ANLQWAVAQQ PNNTVLVERY REVRSLRAKG ELSLPSSIGL ERRTNLFMQA SSAAELGFLR SHKDQWRPT

References

[1]

"Complete sequence of Synechococcus sp. CC9605." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9605.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000110 Genomic DNA. Translation: ABB34724.1.
RefSeq	YP_381279.1. NC_007516.1.
3D structure databases
ProteinModelPortal	Q3AL08.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AL08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3736896.
GenomeReviews	Gene locus Syncc9605_0966 in contig CP000110_GR.
KEGG	syd:Syncc9605_0966.
NMPDR	fig|110662.3.peg.296.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0491.
HOGENOM	HBG753931.
OMA	ITHHHRD.
PhylomeDB	Q3AL08.
ProtClustDB	CLSK647525.
Enzyme and pathway databases
BioCyc	SSP1131:SYNCC9605_0966-MONOMER.
Family and domain databases
HAMAP	MF_01374. Glyoxalase_2. [Tree]
InterPro	IPR001279. Beta-lactamas-like. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view]
KO	K01069.
PANTHER	PTHR11935:SF7. PTHR11935:SF7. 1 hit.
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
TIGRFAMs	TIGR03413. GSH_gloB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLO2_SYNSC

Accession

Primary (citable) accession number: Q3AL08

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program