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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciSSP110662:G1G50-1356-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Syncc9605_1307
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201941 – 338Methionyl-tRNA formyltransferaseAdd BLAST338

Interactioni

Protein-protein interaction databases

STRINGi110662.Syncc9605_1307

Structurei

3D structure databases

ProteinModelPortaliQ3AK21
SMRiQ3AK21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AK21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILFWGTPA YAVPTLDALH GAGHTIVGVV TQPDRRRGRG KQLVPSPVKA
60 70 80 90 100
RAEELGLPVF TPERIRRDDD CKAKLAALGA DASVVVAFGQ ILPKDVLEQP
110 120 130 140 150
PLGSWNGHGS LLPRWRGAGP IQWALLEGDQ ETGVGIMAME EGLDTGPVLL
160 170 180 190 200
EQRTPIELLD TSIALAERLS ALTAELMVQA MPLIEAAGTG PEDERLAKLN
210 220 230 240 250
VRVQAEGSTY ARMLEKQDFQ LDWSASALSI HRKVMGLHPG AFTQLHDKRL
260 270 280 290 300
KVLRTEPLIE RLQDQLSTEG RSLVGQWPTG GHPPGTILAM IEDLGLVVSS
310 320 330
SGCPLLIREA QLEGKARSTA PALLQQLKAT LGDRFGEV
Length:338
Mass (Da):36,496
Last modified:November 22, 2005 - v1
Checksum:i0EE1E24556CC62E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB35061.1
RefSeqiWP_011364280.1, NC_007516.1

Genome annotation databases

EnsemblBacteriaiABB35061; ABB35061; Syncc9605_1307
KEGGisyd:Syncc9605_1307

Similar proteinsi

Entry informationi

Entry nameiFMT_SYNSC
AccessioniPrimary (citable) accession number: Q3AK21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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