Reviewed, UniProtKB/Swiss-Prot Q3AK18 (ACSF_SYNSC)

Names and origin

Protein names

Recommended name:
    Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase
      Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase
    EC=1.14.13.81

Gene names

Name:	acsF
Ordered Locus Names:	Syncc9605_1310

Organism

Synechococcus sp. (strain CC9605) [Complete proteome] [HAMAP]

Taxonomic identifier

110662 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity.
Catalytic activity	Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O(2) = 13(1)-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP(+) + H(2)O. 13(1)-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O(2) = 13(1)-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP(+) + 2 H(2)O. 13(1)-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O(2) = divinylprotochlorophyllide + NADP(+) + 2 H(2)O.
Cofactor	Iron By similarity.
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent).
Sequence similarities	Belongs to the acsF family.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Photosynthesis
Ligand	Iron Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: HAMAP
Molecular function	iron ion binding Inferred from electronic annotation. Source: HAMAP magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase		PRO_1000070556

Sequences

	Sequence		Length	Mass (Da)
	Q3AK18-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: B56D3A44D223E85F	FASTA	356	41,212
	10 20 30 40 50 60 MVPPTAVAEG SAVAIKDPVK DTILTPRFYT TDFEAMAAMD LQPNEAELEA ICEEFRKDYN 70 80 90 100 110 120 RHHFVRNEEF EGAADKLDPE TRKVFIEFLE QSCTSEFSGF LLYKELSRRI KAKNPLLAEC 130 140 150 160 170 180 FAHMARDEAR HAGFLNKSMS DFGMQLDLGF LTANKDYTFF KPKFIFYATY LSEKIGYWRY 190 200 210 220 230 240 IAIYRHLEKN PDSKIFPIFN FFENWCQDEN RHGDFFDALM KAQPDTVRGP IAKLWCRFFL 250 260 270 280 290 300 LAVFATMYVR DVARKEFYEA LGLDARTYDK MVIEKTNETS ARVFPVVLDV NNDKFWTRLE 310 320 330 340 350 RLVANNAALD KADASDAIAP VKLLRKLPFW IGNGAEMAKL FLMPAIDSDR FQPAVR

References

[1]

"Complete sequence of Synechococcus sp. CC9605." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000110 Genomic DNA. Translation: ABB35064.1.
RefSeq	YP_381619.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3735865.
GenomeReviews	Gene locus Syncc9605_1310 in contig CP000110_GR.
KEGG	syd:Syncc9605_1310.
NMPDR	fig|110662.3.peg.278.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3AK18.
Enzyme and pathway databases
BioCyc	SSP1131:SYNCC9605_1310-MON.
Family and domain databases
HAMAP	MF_01840. [Tree]
InterPro	IPR008434. AcsF. IPR003251. Rubrerythrin. [Graphical view]
Pfam	PF02915. Rubrerythrin. 1 hit. [Graphical view]
TIGRFAMs	TIGR02029. AcsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACSF_SYNSC

Accession

Primary (citable) accession number: Q3AK18

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 22, 2005
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)