Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3AJU8 (SYL_SYNSC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Syncc9605_1380
OrganismSynechococcus sp. (strain CC9605) [Complete proteome] [HAMAP]
Taxonomic identifier110662 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length875 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 875875Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334829

Regions

Motif60 – 7011"HIGH" region HAMAP-Rule MF_00049
Motif634 – 6385"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6371ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3AJU8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: AC3754A1958463C4

FASTA87596,528
        10         20         30         40         50         60 
MPSAGSVNAA NPAVDTSAQT GRYDPTALEQ RWQESWKADG VDTTEVGGEK PGFFALSMFP 

        70         80         90        100        110        120 
YPSGSLHMGH VRNYVITDVI ARVQRMLGHA VLHPMGWDAF GLPAENAAIE RNVDPGEWTD 

       130        140        150        160        170        180 
RNIDQMRAQL DRLGLSIDWS REQATCHSDY YRWTQWLFLE LLEGGLAYRK NATVNWDPVD 

       190        200        210        220        230        240 
QTVLANEQVD GDGRSWRSGA LVEQRQLNQW FLRITDYAEP LLNDLDALKG WPERVRTMQA 

       250        260        270        280        290        300 
NWIGRSEGAE ISFNVEGAQN QTITVFTTRP DTLAGASYVV LAPENELVDS LSSEEQKDTV 

       310        320        330        340        350        360 
EAFRKEVARL STIERTCDDR PKRGVPIGSH VINPLTGVVL PVWIADYVLA EYGTGAVMGV 

       370        380        390        400        410        420 
PAHDQRDIAF AQSNGLPIQQ VIDAEGAAEA IAAGQAWTDA GTLVNSGSFD GTASSEAKGA 

       430        440        450        460        470        480 
ITGHGAEQGW ARSKVTYRLR DWLISRQRYW GCPIPVIHCD NCGAVPVPRE DLPVELPRGI 

       490        500        510        520        530        540 
DLSGKGGSPL SQQSDWVNVA CPRCGKPAKR ETDTMDTFMC SSWYFLRFAD PHNTEKPFSK 

       550        560        570        580        590        600 
EAVNRWLPVK QYVGGIEHAI LHLLYARFFT KALKDRGLID INEPFERLLT QGMVQGVTYR 

       610        620        630        640        650        660 
NATTGKYIAP ADVADAEDPR DPNTGDKLEV LFEKMSKSKY NGVDPAAVID RYGADTARMF 

       670        680        690        700        710        720 
ILFKAPPEKD LEWDDADVEG QFRFLQRLWR LVEAGSARID SLEPMQRPAD LSDADSDVRR 

       730        740        750        760        770        780 
ALHLAIEAVS EDLSDEIQLN TAISELMKLS NAISSTGIDA LSAPVLQEAL SGLVRLLAPF 

       790        800        810        820        830        840 
APHLAEEFWN RLGGSGSVHR QSWPVLDPTA LVQDSVEVVI QVKGKVRGKL QVPASAGKEE 

       850        860        870 
LERLALASDV AEKWLEGAAP RRVIVVPGKL VNLVP 

« Hide

References

[1]"Complete sequence of Synechococcus sp. CC9605."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CC9605.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000110 Genomic DNA. Translation: ABB35134.1.
RefSeqYP_381689.1. NC_007516.1.

3D structure databases

ProteinModelPortalQ3AJU8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING110662.Syncc9605_1380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB35134; ABB35134; Syncc9605_1380.
GeneID3735935.
KEGGsyd:Syncc9605_1380.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAVHRQSWP.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycSSP110662:GJ7R-1419-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_SYNSC
AccessionPrimary (citable) accession number: Q3AJU8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries