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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei637ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Syncc9605_1380
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348291 – 875Leucine--tRNA ligaseAdd BLAST875

Proteomic databases

PRIDEiQ3AJU8

Interactioni

Protein-protein interaction databases

STRINGi110662.Syncc9605_1380

Structurei

3D structure databases

ProteinModelPortaliQ3AJU8
SMRiQ3AJU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi60 – 70"HIGH" regionAdd BLAST11
Motifi634 – 638"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AJU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSAGSVNAA NPAVDTSAQT GRYDPTALEQ RWQESWKADG VDTTEVGGEK
60 70 80 90 100
PGFFALSMFP YPSGSLHMGH VRNYVITDVI ARVQRMLGHA VLHPMGWDAF
110 120 130 140 150
GLPAENAAIE RNVDPGEWTD RNIDQMRAQL DRLGLSIDWS REQATCHSDY
160 170 180 190 200
YRWTQWLFLE LLEGGLAYRK NATVNWDPVD QTVLANEQVD GDGRSWRSGA
210 220 230 240 250
LVEQRQLNQW FLRITDYAEP LLNDLDALKG WPERVRTMQA NWIGRSEGAE
260 270 280 290 300
ISFNVEGAQN QTITVFTTRP DTLAGASYVV LAPENELVDS LSSEEQKDTV
310 320 330 340 350
EAFRKEVARL STIERTCDDR PKRGVPIGSH VINPLTGVVL PVWIADYVLA
360 370 380 390 400
EYGTGAVMGV PAHDQRDIAF AQSNGLPIQQ VIDAEGAAEA IAAGQAWTDA
410 420 430 440 450
GTLVNSGSFD GTASSEAKGA ITGHGAEQGW ARSKVTYRLR DWLISRQRYW
460 470 480 490 500
GCPIPVIHCD NCGAVPVPRE DLPVELPRGI DLSGKGGSPL SQQSDWVNVA
510 520 530 540 550
CPRCGKPAKR ETDTMDTFMC SSWYFLRFAD PHNTEKPFSK EAVNRWLPVK
560 570 580 590 600
QYVGGIEHAI LHLLYARFFT KALKDRGLID INEPFERLLT QGMVQGVTYR
610 620 630 640 650
NATTGKYIAP ADVADAEDPR DPNTGDKLEV LFEKMSKSKY NGVDPAAVID
660 670 680 690 700
RYGADTARMF ILFKAPPEKD LEWDDADVEG QFRFLQRLWR LVEAGSARID
710 720 730 740 750
SLEPMQRPAD LSDADSDVRR ALHLAIEAVS EDLSDEIQLN TAISELMKLS
760 770 780 790 800
NAISSTGIDA LSAPVLQEAL SGLVRLLAPF APHLAEEFWN RLGGSGSVHR
810 820 830 840 850
QSWPVLDPTA LVQDSVEVVI QVKGKVRGKL QVPASAGKEE LERLALASDV
860 870
AEKWLEGAAP RRVIVVPGKL VNLVP
Length:875
Mass (Da):96,528
Last modified:November 22, 2005 - v1
Checksum:iAC3754A1958463C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB35134.1

Genome annotation databases

EnsemblBacteriaiABB35134; ABB35134; Syncc9605_1380
KEGGisyd:Syncc9605_1380

Similar proteinsi

Entry informationi

Entry nameiSYL_SYNSC
AccessioniPrimary (citable) accession number: Q3AJU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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