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Q3AJU8

- SYL_SYNSC

UniProt

Q3AJU8 - SYL_SYNSC

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Protein
Leucine--tRNA ligase
Gene
leuS, Syncc9605_1380
Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei637 – 6371ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP110662:GJ7R-1419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Syncc9605_1380
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002711: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Leucine--tRNA ligaseUniRule annotation
PRO_0000334829Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi110662.Syncc9605_1380.

Structurei

3D structure databases

ProteinModelPortaliQ3AJU8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi60 – 7011"HIGH" regionUniRule annotation
Add
BLAST
Motifi634 – 6385"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVHRQSWP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AJU8-1 [UniParc]FASTAAdd to Basket

« Hide

MPSAGSVNAA NPAVDTSAQT GRYDPTALEQ RWQESWKADG VDTTEVGGEK    50
PGFFALSMFP YPSGSLHMGH VRNYVITDVI ARVQRMLGHA VLHPMGWDAF 100
GLPAENAAIE RNVDPGEWTD RNIDQMRAQL DRLGLSIDWS REQATCHSDY 150
YRWTQWLFLE LLEGGLAYRK NATVNWDPVD QTVLANEQVD GDGRSWRSGA 200
LVEQRQLNQW FLRITDYAEP LLNDLDALKG WPERVRTMQA NWIGRSEGAE 250
ISFNVEGAQN QTITVFTTRP DTLAGASYVV LAPENELVDS LSSEEQKDTV 300
EAFRKEVARL STIERTCDDR PKRGVPIGSH VINPLTGVVL PVWIADYVLA 350
EYGTGAVMGV PAHDQRDIAF AQSNGLPIQQ VIDAEGAAEA IAAGQAWTDA 400
GTLVNSGSFD GTASSEAKGA ITGHGAEQGW ARSKVTYRLR DWLISRQRYW 450
GCPIPVIHCD NCGAVPVPRE DLPVELPRGI DLSGKGGSPL SQQSDWVNVA 500
CPRCGKPAKR ETDTMDTFMC SSWYFLRFAD PHNTEKPFSK EAVNRWLPVK 550
QYVGGIEHAI LHLLYARFFT KALKDRGLID INEPFERLLT QGMVQGVTYR 600
NATTGKYIAP ADVADAEDPR DPNTGDKLEV LFEKMSKSKY NGVDPAAVID 650
RYGADTARMF ILFKAPPEKD LEWDDADVEG QFRFLQRLWR LVEAGSARID 700
SLEPMQRPAD LSDADSDVRR ALHLAIEAVS EDLSDEIQLN TAISELMKLS 750
NAISSTGIDA LSAPVLQEAL SGLVRLLAPF APHLAEEFWN RLGGSGSVHR 800
QSWPVLDPTA LVQDSVEVVI QVKGKVRGKL QVPASAGKEE LERLALASDV 850
AEKWLEGAAP RRVIVVPGKL VNLVP 875
Length:875
Mass (Da):96,528
Last modified:November 22, 2005 - v1
Checksum:iAC3754A1958463C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000110 Genomic DNA. Translation: ABB35134.1.
RefSeqiWP_011364351.1. NC_007516.1.
YP_381689.1. NC_007516.1.

Genome annotation databases

EnsemblBacteriaiABB35134; ABB35134; Syncc9605_1380.
GeneIDi3735935.
KEGGisyd:Syncc9605_1380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000110 Genomic DNA. Translation: ABB35134.1 .
RefSeqi WP_011364351.1. NC_007516.1.
YP_381689.1. NC_007516.1.

3D structure databases

ProteinModelPortali Q3AJU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 110662.Syncc9605_1380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB35134 ; ABB35134 ; Syncc9605_1380 .
GeneIDi 3735935.
KEGGi syd:Syncc9605_1380.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VHRQSWP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSP110662:GJ7R-1419-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. CC9605."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9605.

Entry informationi

Entry nameiSYL_SYNSC
AccessioniPrimary (citable) accession number: Q3AJU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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