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Q3AJU8

- SYL_SYNSC

UniProt

Q3AJU8 - SYL_SYNSC

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei637 – 6371ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP110662:GJ7R-1419-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Syncc9605_1380
    OrganismiSynechococcus sp. (strain CC9605)
    Taxonomic identifieri110662 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002711: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 875875Leucine--tRNA ligasePRO_0000334829Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi110662.Syncc9605_1380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3AJU8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi60 – 7011"HIGH" regionAdd
    BLAST
    Motifi634 – 6385"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVHRQSWP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3AJU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSAGSVNAA NPAVDTSAQT GRYDPTALEQ RWQESWKADG VDTTEVGGEK    50
    PGFFALSMFP YPSGSLHMGH VRNYVITDVI ARVQRMLGHA VLHPMGWDAF 100
    GLPAENAAIE RNVDPGEWTD RNIDQMRAQL DRLGLSIDWS REQATCHSDY 150
    YRWTQWLFLE LLEGGLAYRK NATVNWDPVD QTVLANEQVD GDGRSWRSGA 200
    LVEQRQLNQW FLRITDYAEP LLNDLDALKG WPERVRTMQA NWIGRSEGAE 250
    ISFNVEGAQN QTITVFTTRP DTLAGASYVV LAPENELVDS LSSEEQKDTV 300
    EAFRKEVARL STIERTCDDR PKRGVPIGSH VINPLTGVVL PVWIADYVLA 350
    EYGTGAVMGV PAHDQRDIAF AQSNGLPIQQ VIDAEGAAEA IAAGQAWTDA 400
    GTLVNSGSFD GTASSEAKGA ITGHGAEQGW ARSKVTYRLR DWLISRQRYW 450
    GCPIPVIHCD NCGAVPVPRE DLPVELPRGI DLSGKGGSPL SQQSDWVNVA 500
    CPRCGKPAKR ETDTMDTFMC SSWYFLRFAD PHNTEKPFSK EAVNRWLPVK 550
    QYVGGIEHAI LHLLYARFFT KALKDRGLID INEPFERLLT QGMVQGVTYR 600
    NATTGKYIAP ADVADAEDPR DPNTGDKLEV LFEKMSKSKY NGVDPAAVID 650
    RYGADTARMF ILFKAPPEKD LEWDDADVEG QFRFLQRLWR LVEAGSARID 700
    SLEPMQRPAD LSDADSDVRR ALHLAIEAVS EDLSDEIQLN TAISELMKLS 750
    NAISSTGIDA LSAPVLQEAL SGLVRLLAPF APHLAEEFWN RLGGSGSVHR 800
    QSWPVLDPTA LVQDSVEVVI QVKGKVRGKL QVPASAGKEE LERLALASDV 850
    AEKWLEGAAP RRVIVVPGKL VNLVP 875
    Length:875
    Mass (Da):96,528
    Last modified:November 22, 2005 - v1
    Checksum:iAC3754A1958463C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000110 Genomic DNA. Translation: ABB35134.1.
    RefSeqiWP_011364351.1. NC_007516.1.
    YP_381689.1. NC_007516.1.

    Genome annotation databases

    EnsemblBacteriaiABB35134; ABB35134; Syncc9605_1380.
    GeneIDi3735935.
    KEGGisyd:Syncc9605_1380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000110 Genomic DNA. Translation: ABB35134.1 .
    RefSeqi WP_011364351.1. NC_007516.1.
    YP_381689.1. NC_007516.1.

    3D structure databases

    ProteinModelPortali Q3AJU8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 110662.Syncc9605_1380.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB35134 ; ABB35134 ; Syncc9605_1380 .
    GeneIDi 3735935.
    KEGGi syd:Syncc9605_1380.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VHRQSWP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SSP110662:GJ7R-1419-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Synechococcus sp. CC9605."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CC9605.

    Entry informationi

    Entry nameiSYL_SYNSC
    AccessioniPrimary (citable) accession number: Q3AJU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3