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Q3AJU8

- SYL_SYNSC

UniProt

Q3AJU8 - SYL_SYNSC

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei637 – 6371ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP110662:GJ7R-1419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Syncc9605_1380
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002711: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Leucine--tRNA ligasePRO_0000334829Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi110662.Syncc9605_1380.

Structurei

3D structure databases

ProteinModelPortaliQ3AJU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi60 – 7011"HIGH" regionAdd
BLAST
Motifi634 – 6385"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVHRQSWP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AJU8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSAGSVNAA NPAVDTSAQT GRYDPTALEQ RWQESWKADG VDTTEVGGEK
60 70 80 90 100
PGFFALSMFP YPSGSLHMGH VRNYVITDVI ARVQRMLGHA VLHPMGWDAF
110 120 130 140 150
GLPAENAAIE RNVDPGEWTD RNIDQMRAQL DRLGLSIDWS REQATCHSDY
160 170 180 190 200
YRWTQWLFLE LLEGGLAYRK NATVNWDPVD QTVLANEQVD GDGRSWRSGA
210 220 230 240 250
LVEQRQLNQW FLRITDYAEP LLNDLDALKG WPERVRTMQA NWIGRSEGAE
260 270 280 290 300
ISFNVEGAQN QTITVFTTRP DTLAGASYVV LAPENELVDS LSSEEQKDTV
310 320 330 340 350
EAFRKEVARL STIERTCDDR PKRGVPIGSH VINPLTGVVL PVWIADYVLA
360 370 380 390 400
EYGTGAVMGV PAHDQRDIAF AQSNGLPIQQ VIDAEGAAEA IAAGQAWTDA
410 420 430 440 450
GTLVNSGSFD GTASSEAKGA ITGHGAEQGW ARSKVTYRLR DWLISRQRYW
460 470 480 490 500
GCPIPVIHCD NCGAVPVPRE DLPVELPRGI DLSGKGGSPL SQQSDWVNVA
510 520 530 540 550
CPRCGKPAKR ETDTMDTFMC SSWYFLRFAD PHNTEKPFSK EAVNRWLPVK
560 570 580 590 600
QYVGGIEHAI LHLLYARFFT KALKDRGLID INEPFERLLT QGMVQGVTYR
610 620 630 640 650
NATTGKYIAP ADVADAEDPR DPNTGDKLEV LFEKMSKSKY NGVDPAAVID
660 670 680 690 700
RYGADTARMF ILFKAPPEKD LEWDDADVEG QFRFLQRLWR LVEAGSARID
710 720 730 740 750
SLEPMQRPAD LSDADSDVRR ALHLAIEAVS EDLSDEIQLN TAISELMKLS
760 770 780 790 800
NAISSTGIDA LSAPVLQEAL SGLVRLLAPF APHLAEEFWN RLGGSGSVHR
810 820 830 840 850
QSWPVLDPTA LVQDSVEVVI QVKGKVRGKL QVPASAGKEE LERLALASDV
860 870
AEKWLEGAAP RRVIVVPGKL VNLVP
Length:875
Mass (Da):96,528
Last modified:November 22, 2005 - v1
Checksum:iAC3754A1958463C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA. Translation: ABB35134.1.
RefSeqiWP_011364351.1. NC_007516.1.
YP_381689.1. NC_007516.1.

Genome annotation databases

EnsemblBacteriaiABB35134; ABB35134; Syncc9605_1380.
GeneIDi3735935.
KEGGisyd:Syncc9605_1380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA. Translation: ABB35134.1 .
RefSeqi WP_011364351.1. NC_007516.1.
YP_381689.1. NC_007516.1.

3D structure databases

ProteinModelPortali Q3AJU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 110662.Syncc9605_1380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB35134 ; ABB35134 ; Syncc9605_1380 .
GeneIDi 3735935.
KEGGi syd:Syncc9605_1380.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VHRQSWP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSP110662:GJ7R-1419-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Synechococcus sp. CC9605."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CC9605.

Entry informationi

Entry nameiSYL_SYNSC
AccessioniPrimary (citable) accession number: Q3AJU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3