Q3AJT9 (ARGC_SYNSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Syncc9605_1389

Organism

Synechococcus sp. (strain CC9605) [Complete proteome] [HAMAP]

Taxonomic identifier

110662 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011074
Sites
	Active site	160	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3AJT9 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 5800D4B1BC87BD19	FASTA	357	38,053
	10 20 30 40 50 60 MATVKGGRVA VIGASGYGGL QTIRLLQGHP GLSVSFLGGE RSAGQRWSSV CSFLPLPDDP 70 80 90 100 110 120 KVESADPDRI AACSDFAVLS LPNGLACQLA PQLLERGVRV VDLSADFRYR SLEQWLQVYA 130 140 150 160 170 180 KEAGSLNRQD AELCSSAVYG LPEWNGPAIA DAKLVAAPGC FPTASLMPLL PFLKQGLIET 190 200 210 220 230 240 SGIIIDAKTG TSGGGRVPKE AMLLAEASES IAPYGVIGHR HTSEIEQMAM EVAGQDIRLQ 250 260 270 280 290 300 FTPHLVPMVR GLLSTVYARL RDPGLTAEDC TTVLEAIYRH HPCVQVLPVG TYPATKWARH 310 320 330 340 350 TNRALLSVQV DTRTGQLVLM SAIDNLIKGQ AGQGVQCINL MAGLAPETGL PLQSFYP

References

[1]

"Complete sequence of Synechococcus sp. CC9605." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9605.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000110 Genomic DNA. Translation: ABB35143.1.
RefSeq	YP_381698.1. NC_007516.1.
3D structure databases
HSSP	HSSP built from PDB template 1VKN based on UniProtKB Q9X2A2.
ProteinModelPortal	Q3AJT9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AJT9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3735944.
GenomeReviews	Gene locus Syncc9605_1389 in contig CP000110_GR.
KEGG	syd:Syncc9605_1389.
NMPDR	fig|110662.3.peg.818.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	Q3AJT9.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	SSP1131:SYNCC9605_1389-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_SYNSC

Accession

Primary (citable) accession number: Q3AJT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program