Q3AIK8 (DAPB_SYNSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Syncc9605_1829

Organism

Synechococcus sp. (strain CC9605) [Complete proteome] [HAMAP]

Taxonomic identifier

110662 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008656

Sequences

	Sequence		Length	Mass (Da)
	Q3AIK8 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: E71EDF0EEF40F675	FASTA	277	28,956
	10 20 30 40 50 60 MTAPIPVVVA GALGRMGAEV IKAVVGAEDC SLVGAIDNTP GKEGADVGLE LGLGELEVAV 70 80 90 100 110 120 TADFEGCLCA VSQSVRDSGS GAVLVDFTHP SVVYEHTRAA IAYGVHPVIG TTGLSPEQLN 130 140 150 160 170 180 DLTEFSAKAS VGGAVIPNFS VGMVLLQQAA AAAARFYDHA ELTELHHNRK ADAPSGTCIK 190 200 210 220 230 240 TAELMEELGK SFNPEEVDEH ESLAGCRGGQ RDSGLRLHSV RLPGLVAHQE VMFGAPGETY 250 260 270 TLRHDTIDRS AYMPGVLLTV RKVGNLGSLV YGLERLI

References

[1]

"Complete sequence of Synechococcus sp. CC9605." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CC9605.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000110 Genomic DNA. Translation: ABB35574.1.
RefSeq	YP_382129.1. NC_007516.1.
3D structure databases
HSSP	HSSP built from PDB template 1YL5 based on UniProtKB P72024.
ProteinModelPortal	Q3AIK8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AIK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3736951.
GenomeReviews	Gene locus Syncc9605_1829 in contig CP000110_GR.
KEGG	syd:Syncc9605_1829.
NMPDR	fig|110662.3.peg.2425.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	DRASFMP.
PhylomeDB	Q3AIK8.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	SSP1131:SYNCC9605_1829-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_SYNSC

Accession

Primary (citable) accession number: Q3AIK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program