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Protein

Glutamate 5-kinase

Gene

proB

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7ATPUniRule annotation1
Binding sitei43SubstrateUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Binding sitei142Substrate; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 163ATPUniRule annotation2
Nucleotide bindingi205 – 211ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP110662:G1G50-1932-MONOMER
UniPathwayiUPA00098; UER00359

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:Syncc9605_1867
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530081 – 357Glutamate 5-kinaseAdd BLAST357

Proteomic databases

PRIDEiQ3AIH2

Interactioni

Protein-protein interaction databases

STRINGi110662.Syncc9605_1867

Structurei

3D structure databases

ProteinModelPortaliQ3AIH2
SMRiQ3AIH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 353PUAUniRule annotationAdd BLAST84

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGT Bacteria
COG0263 LUCA
HOGENOMiHOG000246368
KOiK00931
OMAiTHEIRFG
OrthoDBiPOG091H00OF

Family and domain databases

Gene3Di2.30.130.10, 1 hit
3.40.1160.10, 1 hit
HAMAPiMF_00456 ProB, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR001057 Glu/AcGlu_kinase
IPR011529 Glu_5kinase
IPR005715 Glu_5kinase/COase_Synthase
IPR019797 Glutamate_5-kinase_CS
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF01472 PUA, 1 hit
PIRSFiPIRSF000729 GK, 1 hit
PRINTSiPR00474 GLU5KINASE
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR01027 proB, 1 hit
PROSITEiView protein in PROSITE
PS00902 GLUTAMATE_5_KINASE, 1 hit
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AIH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLWVVKIGT SLLRGETATT IDGYARCFAG AMDRGDQVVL VTSGAVGLGC
60 70 80 90 100
QKLALTNRPD TVVALQAAAA IGQGALMGLY ERAMARHGRS VAQVLLTRSD
110 120 130 140 150
LADRRRYQNA SGTLRQLLSW GVLPVINEND ALSPAELRFG DNDTLSALVA
160 170 180 190 200
AAVEAQQLIL LTDVDRLYSS DPRVDANAEP ISDIRHPREL DSLEQGAGDG
210 220 230 240 250
GRWGTGGMTT KLAAARIATA SGITVQLADG RDPARLEALL QGQRGGTVFH
260 270 280 290 300
PHPEPLGNRR SWLAHVLRPE GELQLDAGAC AALQHRGASL LLVGVTAVRG
310 320 330 340 350
DFAANQPIQL LDPDGEDLGR GLCSMDSDQL RAAMNDPSPG ESSPVVVHRD

GLVLRSR
Length:357
Mass (Da):37,808
Last modified:November 22, 2005 - v1
Checksum:iC563C686EF0CAD3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB35610.1
RefSeqiWP_011364819.1, NC_007516.1

Genome annotation databases

EnsemblBacteriaiABB35610; ABB35610; Syncc9605_1867
KEGGisyd:Syncc9605_1867

Similar proteinsi

Entry informationi

Entry nameiPROB_SYNSC
AccessioniPrimary (citable) accession number: Q3AIH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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