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Protein

Peptide deformylase

Gene

def

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi121IronUniRule annotation1
Metal bindingi163IronUniRule annotation1
Active sitei164UniRule annotation1
Metal bindingi167IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciSSP110662:G1G50-2349-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:Syncc9605_2274
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002711 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003011161 – 201Peptide deformylaseAdd BLAST201

Interactioni

Protein-protein interaction databases

STRINGi110662.Syncc9605_2274

Structurei

3D structure databases

ProteinModelPortaliQ3AHC4
SMRiQ3AHC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243509
KOiK01462
OMAiVCIQHEI
OrthoDBiPOG091H02B0

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AHC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSFAELAR QADKSRDTML VPKTALETPP LEIHTLGDEV LRQPARRIGK
60 70 80 90 100
VNEQVRELAR DMLRSMYTAK GIGLAAPQVG IHQQLLVIDL DLENAATPPL
110 120 130 140 150
VLINPEITAA SAGLDTYEEG CLSIPGVYLD VVRPTAIELS FRDEMGRPRK
160 170 180 190 200
MKADGLMARC IQHEMDHLNG VLFVDRVTDQ DGLQKELKEK GFERQDVRSV

A
Length:201
Mass (Da):22,256
Last modified:November 22, 2005 - v1
Checksum:i872D7D5102D3F5FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB36008.1
RefSeqiWP_011365206.1, NC_007516.1

Genome annotation databases

EnsemblBacteriaiABB36008; ABB36008; Syncc9605_2274
KEGGisyd:Syncc9605_2274

Similar proteinsi

Entry informationi

Entry nameiDEF_SYNSC
AccessioniPrimary (citable) accession number: Q3AHC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 22, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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