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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Synechococcus sp. (strain CC9605)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSSP110662:G1G50-2411-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Syncc9605_2332
OrganismiSynechococcus sp. (strain CC9605)
Taxonomic identifieri110662 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei131 – 151HelicalUniRule annotationAdd BLAST21
Transmembranei160 – 180HelicalUniRule annotationAdd BLAST21
Transmembranei206 – 226HelicalUniRule annotationAdd BLAST21
Transmembranei234 – 254HelicalUniRule annotationAdd BLAST21
Transmembranei264 – 284HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002502721 – 287Undecaprenyl-diphosphataseAdd BLAST287

Interactioni

Protein-protein interaction databases

STRINGi110662.Syncc9605_2332

Structurei

3D structure databases

SMRiQ3AH68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AH68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPSASLNL VEACWRDLVL GVVQGLTEFL PISSTAHLKV VPELLGWGDP
60 70 80 90 100
GVSVTAAIQL GSIAAVIAYF RTDLSQVLRG VSRAFRYGQW REPEARLGFA
110 120 130 140 150
MVVGTLPILV IGLGIKFAWS QGYEQSPLRS IPSIAIVSIV MALLLALAEQ
160 170 180 190 200
VGARSKQLDV VLGRDGLLVG LAQALALLPG VSRSGSTLTA ALFDGWQRAD
210 220 230 240 250
AARFSFLLGI PGITIAGLVE LKDALAASPG NGPLPLLVGI GSAAVVSWLA
260 270 280
IDWLLKFLQR NSTWLFVAYR LVFGLLLLVW WGVYGSH
Length:287
Mass (Da):30,539
Last modified:November 22, 2005 - v1
Checksum:i7B275EC8A4904D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000110 Genomic DNA Translation: ABB36064.1
RefSeqiWP_011365262.1, NC_007516.1

Genome annotation databases

EnsemblBacteriaiABB36064; ABB36064; Syncc9605_2332
KEGGisyd:Syncc9605_2332

Entry informationi

Entry nameiUPPP_SYNSC
AccessioniPrimary (citable) accession number: Q3AH68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 22, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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