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Q3AFT8 (SYR_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:CHY_0124
OrganismCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]
Taxonomic identifier246194 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242003

Regions

Motif132 – 14211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q3AFT8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 8A1CC2CEFFB8D1E1

FASTA55763,058
        10         20         30         40         50         60 
MEYLLQRITG EIAGSLRRAA VKAGYLDAED ELAFELEKPK EKAHGDLATN LAMLLTKKAR 

        70         80         90        100        110        120 
KNPREIAATL LEYLEIPAVV ERVEIAGPGF INFYFKKDWV VAVIPEILSF GEKYGRLAIG 

       130        140        150        160        170        180 
AGKRVQVEFV SANPTGLLHM GNGRGAALGD ILANILTEAG YEVSREYYIN DAGNQIENFN 

       190        200        210        220        230        240 
KSVEARYLEL LGYKVEFPEE GYHGEDIIDT ARNIVARFGD RFIHLPEKER QEALGKIALE 

       250        260        270        280        290        300 
EKLQSIKKSL ENFGVKYDVW FSERSLHESG EVEKTVKLLL ERGYLYEKDG ALWFAASKLG 

       310        320        330        340        350        360 
EEKDEVLVRK NGVPTYYAAD IAYHKNKFDR GFDLVINIWG ADHHGHVSRM KTALKALGYD 

       370        380        390        400        410        420 
PERLIVILMQ LVRLFQGGEL VRMSKRTGQY ITLDELVEEV GVDAARYFFV MRSHDAHLDF 

       430        440        450        460        470        480 
DLDLAKEKSN ENPVYYIQYA HARIMSLYRQ CNEQGVTLPP VEDVDLAILS SEAELNLLRH 

       490        500        510        520        530        540 
LAEFPVEIEK CATALAPHHL ARYLHELAGY FHTFYNSCRV LGVEENLSKA RLLLVEATRI 

       550 
VLRKGLKMLG VSAPEKM 

« Hide

References

[1]"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901."
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.
PLoS Genet. 1:563-574(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000141 Genomic DNA. Translation: ABB14929.1.
RefSeqYP_358996.1. NC_007503.1.

3D structure databases

ProteinModelPortalQ3AFT8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246194.CHY_0124.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB14929; ABB14929; CHY_0124.
GeneID3726343.
KEGGchy:CHY_0124.
PATRIC21273441. VBICarHyd26463_0120.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMALCNVLAK.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycCHYD246194:GJCN-124-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_CARHZ
AccessionPrimary (citable) accession number: Q3AFT8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries