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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA), ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290Proton donorUniRule annotation1
Active sitei319UniRule annotation1
Active sitei433UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciCHYD246194:G1G5B-218-MONOMER
UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:CHY_0239
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
Proteomesi
  • UP000002706 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002309151 – 464Glucose-6-phosphate isomeraseAdd BLAST464

Proteomic databases

PRIDEiQ3AFH3

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_0239

Structurei

3D structure databases

SMRiQ3AFH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100402
KOiK01810
OMAiSFIIPDD
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AFH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKIDFNNV FHPYLQKERL GEADIDGYKE KFTSALVSLR EKKEKGELGF
60 70 80 90 100
FHLPYLPEEE IAEIEKTARE VREKFKYFVV LGIGGSALGP LAVHTALNNL
110 120 130 140 150
RYNELSEELR GGPKFYVEDN IDPERMASLL KVIEPEKTVF NVITKSGATA
160 170 180 190 200
ETLSQLLIVT EVLKKKVGKR FTEHLIFTTD PEKGSLRALA RELGVKTFAI
210 220 230 240 250
PPNVGGRFSE LTPVGLLPAA VTGINIRELL AGAREMAERC ERENLWENPA
260 270 280 290 300
GLAAAIHVLL LERGKNMAVM MPYADSLKYM ADWYAQLLGE SIGKRLNRRG
310 320 330 340 350
EEVFVGQTPV KALGVTDQHS QVQLYTEGPF DKLLIFLEVE RYRNRVVIPP
360 370 380 390 400
DFPQYAELKF LGGHTLNELI IAEKKATEFA LLKARRPNYT VIFPEVNPYT
410 420 430 440 450
VGELLYFLEA KIAFMGEYLD INAFDQPGVE EGKKATYALL GREGFEEKRQ
460
EVLKVKKEPR FILE
Length:464
Mass (Da):52,456
Last modified:November 22, 2005 - v1
Checksum:iF8F6C53153B03221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA Translation: ABB14260.1
RefSeqiWP_011343187.1, NC_007503.1

Genome annotation databases

EnsemblBacteriaiABB14260; ABB14260; CHY_0239
KEGGichy:CHY_0239

Similar proteinsi

Entry informationi

Entry nameiG6PI_CARHZ
AccessioniPrimary (citable) accession number: Q3AFH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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