Q3AFA8 (MURI_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	CHY_0306

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Glutamate racemase HAMAP MF_00258		PRO_1000078555

Sequences

	Sequence		Length	Mass (Da)
	Q3AFA8 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 4CD8E1B26EF3F4BF	FASTA	265	29,668
	10 20 30 40 50 60 MDKASLGIGI FDSGVGGVTV LKELINLLPG ENFYYLGDTA HVPYGSKSKE ELLILGDAII 70 80 90 100 110 120 RFFLKLGVKM VVFACNTSSA ITLPILKERY PVLMEGMLEP LRKNMPAKAK VGVLATEATV 130 140 150 160 170 180 KSGLYQKKLM ETNKFQEVYM IACPQYVPLI EKGIVSGKEV EEATREYFEP LLKEEVRDVV 190 200 210 220 230 240 LGCTHYPFLT ETIQKLYPKI QVIDPAAYVA REVYRKLKEN KLLGENGGKV QFYVTGDEKS 250 260 LKNLGSLYLG YNIDRVQKID LEVIV

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000141 Genomic DNA. Translation: ABB14358.1.
RefSeq	YP_359176.1. NC_007503.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZUW based on UniProtKB P94556.
ProteinModelPortal	Q3AFA8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AFA8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3728533.
GenomeReviews	Gene locus CHY_0306 in contig CP000141_GR.
KEGG	chy:CHY_0306.
NMPDR	fig|246194.3.peg.353.
PATRIC	21273783. VBICarHyd26463_0290.
TIGR	CHY_0306.
Phylogenomic databases
eggNOG	COG0796.
HOGENOM	HBG645102.
OMA	ATINSSY.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_0306-MONOMER.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. False negative. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_CARHZ

Accession

Primary (citable) accession number: Q3AFA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program