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Q3AFA0 (RNPH_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonuclease PH

Short name=RNase PH
EC=2.7.7.56
Alternative name(s):
tRNA nucleotidyltransferase
Gene names
Name:rph
Ordered Locus Names:CHY_0314
OrganismCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]
Taxonomic identifier246194 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteriaceaeCarboxydothermus

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates By similarity. HAMAP MF_00564

Catalytic activity

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. HAMAP MF_00564

Sequence similarities

Belongs to the RNase PH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Ribonuclease PH HAMAP MF_00564
PRO_1000061130

Sequences

Sequence LengthMass (Da)Tools
Q3AFA0 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 438344CFB5B0F5F7

FASTA25427,772
        10         20         30         40         50         60 
MRIDGREKDQ LRTVKITTNY IKHAEGSVLI EMGDTRVVCT ATVEDKVPPF AKGEGKGWIT 

        70         80         90        100        110        120 
AEYGMLPRST ETRNVREATK GRQSGRTLEI QRLIGRALRG VVDLKALGER TLWIDCDVIQ 

       130        140        150        160        170        180 
ADGGTRTAAI TGSFVALALA LNKLVEEGIL PVIPLKDFVA AVSVGIVDGE EILDLNFEED 

       190        200        210        220        230        240 
SKALVDMNVV MTGSNRFVEV QGTGEEATFS MEELQRLLTL AQKGIRELIE LQKQALGDIA 

       250 
RRIGMENAAD SNSQ 

« Hide

References

[1]"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901."
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.
PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000141 Genomic DNA. Translation: ABB13662.1.
RefSeqYP_359184.1. NC_007503.1.

3D structure databases

HSSPHSSP built from PDB template 2BA1 based on UniProtKB O29756.
ProteinModelPortalQ3AFA0.
SMRQ3AFA0. Positions 1-238.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3AFA0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3726312.
GenomeReviewsGene locus CHY_0314 in contig CP000141_GR.
KEGGchy:CHY_0314.
NMPDRfig|246194.3.peg.402.
PATRIC21273799. VBICarHyd26463_0298.
TIGRCHY_0314.

Phylogenomic databases

eggNOGCOG0689.
HOGENOMHBG737187.
OMAMLPRATG.
ProtClustDBPRK00173.

Enzyme and pathway databases

BioCycCHYD246194:CHY_0314-MONOMER.

Family and domain databases

HAMAPMF_00564. RNase_PH.
[Tree]
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
KOK00989.
PfamPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMSSF55666. 3_ExoRNase. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR01966. RNasePH. 1 hit.
PROSITEPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNPH_CARHZ
AccessionPrimary (citable) accession number: Q3AFA0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families