Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3AF30

- SYL_CARHZ

UniProt

Q3AF30 - SYL_CARHZ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei586 – 5861ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCHYD246194:GJCN-394-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CHY_0393
    OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
    Taxonomic identifieri246194 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
    ProteomesiUP000002706: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 821821Leucine--tRNA ligasePRO_0000334741Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246194.CHY_0393.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3AF30.
    SMRiQ3AF30. Positions 3-755.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi583 – 5875"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3AF30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQERYDFKAI EAKWQKKWEE LKLYEVDDFS EKPKYYCLEM FPYPSGKLHM    50
    GHVRNYSIGD VVARYKRMRG YAVLHPMGWD AFGLPAENAA IKHGNVHPAD 100
    WTWDNIANMR RQLKELGISY DWRREIATCH PEYYRWTQWL FLQFYKKGLA 150
    YKKKAPVNWC PGCQTVLANE QVIDGECERC HSRVEKKELE QWFFKITAYA 200
    ERLLQDIKKL TGWPEKVKIM QENWIGRSEG AEITFKIKGH EETISVFTTR 250
    PDTIFGVTYM VLAPEHPLVE KISRGTQYEK DVLEFKRKMM YLSEIERTAE 300
    TAEKEGVFTG AYAINPFTGE EIPILLANYV LVEYGTGAVM GVPAHDQRDF 350
    LFAKKYNLPI KVVITPPGQE LKAEELTEAY TGEGILVNSG EFTGLANKEA 400
    IRIITQEAEK RGFGKYRVNY RLRDWLISRQ RYWGAPIPVL YCEKCGIVPV 450
    PEDQLPVVLP YNVEFRPTGE SPLKYVPEFL NATCPECGGP ATRETDTMDT 500
    FICSSWYYYR YTSPRDKQQP WSKEKVERWL PVDQYIGGVE HAILHLLYSR 550
    FFTKVLYDLG LVHVDEPFTN LLTQGMVLKD GAKMSKSKGN VVSPEEIVEK 600
    YGADTARLFI LFAAPPERDL EWSDQGVEGS FRFLNRVWRL IYQTKDRISD 650
    ELREFSAKDK ELNRLLHATI KKVTEDIEER FNFNTAISAI MELVNGLYQY 700
    KEGEINPGLL KEALNKLVIL LAPFAPHIAE ELWEALGNKQ SVHLEKWPEY 750
    DEEALITEEV EIVIQVNGKV KDRVMVPRNA AEDELKEIAL NTPKIKELTA 800
    DKKIIKVIIV PEKLINIVVA G 821
    Length:821
    Mass (Da):95,008
    Last modified:November 22, 2005 - v1
    Checksum:i52887B954D2593AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000141 Genomic DNA. Translation: ABB15559.1.
    RefSeqiWP_011343330.1. NC_007503.1.
    YP_359254.1. NC_007503.1.

    Genome annotation databases

    EnsemblBacteriaiABB15559; ABB15559; CHY_0393.
    GeneIDi3727664.
    KEGGichy:CHY_0393.
    PATRICi21273949. VBICarHyd26463_0365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000141 Genomic DNA. Translation: ABB15559.1 .
    RefSeqi WP_011343330.1. NC_007503.1.
    YP_359254.1. NC_007503.1.

    3D structure databases

    ProteinModelPortali Q3AF30.
    SMRi Q3AF30. Positions 3-755.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246194.CHY_0393.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB15559 ; ABB15559 ; CHY_0393 .
    GeneIDi 3727664.
    KEGGi chy:CHY_0393.
    PATRICi 21273949. VBICarHyd26463_0365.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CHYD246194:GJCN-394-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z-2901 / DSM 6008.

    Entry informationi

    Entry nameiSYL_CARHZ
    AccessioniPrimary (citable) accession number: Q3AF30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3