Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q3AEU3 (DCUP_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:CHY_0483
OrganismCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]
Taxonomic identifier246194 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325632

Regions

Region23 – 275Substrate binding By similarity

Sites

Binding site721Substrate By similarity
Binding site1491Substrate By similarity
Binding site2041Substrate By similarity
Binding site3181Substrate By similarity
Site721Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3AEU3 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 4F49F88BEEAABDB8

FASTA35039,153
        10         20         30         40         50         60 
MNDTFLKACR RENTPYTPVW LMRQAGRYMA EYMEIRNKYS FLEMCKTPEL AVEVTLQPVR 

        70         80         90        100        110        120 
KLGVDAAILF ADILLPLEGM GIGFRFARDE GPVIENPVRT IVDVKKVRVI TPEEDVPYVL 

       130        140        150        160        170        180 
EAIKILRREL AGKVPLIGFS GAPFTLASYI IEGGGSKNYI QCKRLMWEAP EAWHELLGKI 

       190        200        210        220        230        240 
AESTVRYLKA QIAAGAQAVQ VFDSWVGTLS PEDYEKYVLP HSKYVFDNLK ETGVPVIHFA 

       250        260        270        280        290        300 
NNAGSMLELV AAAGGDVIGL DWRVSLDRAW QTVGFDRGVQ GNLDPVALFA PKEVIRQKVK 

       310        320        330        340        350 
EILIKAGKRP GHIFNLGHGI HKETPVENAQ YLVEVVHELS SLSYEQLLEA

« Hide

References

[1]"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901."
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.
PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000141 Genomic DNA. Translation: ABB14020.1.
RefSeqYP_359341.1. NC_007503.1.

3D structure databases

ProteinModelPortalQ3AEU3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3AEU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3726459.
GenomeReviewsGene locus CHY_0483 in contig CP000141_GR.
KEGGchy:CHY_0483.
NMPDRfig|246194.3.peg.968.
PATRIC21274119. VBICarHyd26463_0447.
TIGRCHY_0483.

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBCLSK941151.

Enzyme and pathway databases

BioCycCHYD246194:CHY_0483-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_CARHZ
AccessionPrimary (citable) accession number: Q3AEU3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents