Reviewed, UniProtKB/Swiss-Prot Q3AET7 (GCST_CARHZ)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	CHY_0489

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity.
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Aminomethyltransferase HAMAP MF_00259		PRO_1000059082

Sequences

	Sequence		Length	Mass (Da)
	Q3AET7-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 0F6D7AE014B10FB6	FASTA	360	40,036
	10 20 30 40 50 60 MENLKRTPLY EEHIKLGAKM VPFGGWEMPV QYTGILEEHM AVRTDVGMFD VSHMGEIEIT 70 80 90 100 110 120 GKQAERFVNY LITNDVSRLN SGDVIYTTMC YPDGGTVDDL LAYKYSTERY LLVVNAANKD 130 140 150 160 170 180 KDLAHILQYR WDDVTVTDLS DETAEIALQG PRAQEILQKL TAFDLNQIKY FGFAEIEVAG 190 200 210 220 230 240 VPCLVSRTGY TGEDGFEIYF APNLATKIWN ELLNLGVKPA GLGARDTLRF EACLPLYGHE 250 260 270 280 290 300 LSAEITPLEA GLGWAVKFNK EDFIGKEALL AQKNAGLKRK IVGLEMIGAG IPRQGYEIVF 310 320 330 340 350 360 NQRGVGFVTS GTFAPFLKKN LAMAMVDLEA AEIGTEVDVI IRGKGVRARV ISRPFYKRGK

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000141 Genomic DNA. Translation: ABB13918.1.
RefSeq	YP_359347.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3727042.
GenomeReviews	Gene locus CHY_0489 in contig CP000141_GR.
KEGG	chy:CHY_0489.
NMPDR	fig|246194.3.peg.974.
TIGR	CHY_0489.
Phylogenomic databases
HOGENOM	Q3AET7.
OMA	Q3AET7. PFYRGSV.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_0489-MON.
Family and domain databases
HAMAP	MF_00259. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CARHZ

Accession

Primary (citable) accession number: Q3AET7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 22, 2005
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)