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Q3AET5

- GCSPA_CARHZ

UniProt

Q3AET5 - GCSPA_CARHZ

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, CHY_0491
Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-492-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:CHY_0491
OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
ProteomesiUP000002706: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000045640Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi246194.CHY_0491.

Structurei

3D structure databases

ProteinModelPortaliQ3AET5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AET5-1 [UniParc]FASTAAdd to Basket

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MKYTPHTPDE VREMLSSLGL SSIEELFSDI PEEVKLKRPL NLPSGMSELE    50
VKKHLANLAA KNGSADKYTV FLGAGVYDHY VPAVVNHILL RSEFYTAYTP 100
YQAEMSQGVL QSIFEYQTMI CELTGLDITN ASMYDGGSAL AEAALMAVSQ 150
TRRDKVLVLA TVHPEYRSVV KTYTWGPEIE VVEVPYKSGT VDLEKLEELI 200
DDKTAAVLVQ HPNFFGQLEP VEEISRLIHA QKGLLVVAVD PISLGILKPP 250
AEYGADIAVG DGQALGNGLA FGGPHLGFFA ARKDLARRMP GRLVGLTTDK 300
EGNRGFVLTL QAREQHIRRE KATSNICSNQ ALNALAATVY LATVGKKGLK 350
EIALQSLQKA HYAFERLIGE GYEPLFSGPF FKEFVVKVKN EEEITQKLLK 400
HHILAGPGIS RFYPELAPAL MIAVTEKRTR EEIDNLVEVL GGDR 444
Length:444
Mass (Da):48,908
Last modified:November 22, 2005 - v1
Checksum:iA9A0197BAEEB89D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB15168.1.
RefSeqiWP_011343425.1. NC_007503.1.
YP_359349.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB15168; ABB15168; CHY_0491.
GeneIDi3727270.
KEGGichy:CHY_0491.
PATRICi21274131. VBICarHyd26463_0453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB15168.1 .
RefSeqi WP_011343425.1. NC_007503.1.
YP_359349.1. NC_007503.1.

3D structure databases

ProteinModelPortali Q3AET5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246194.CHY_0491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB15168 ; ABB15168 ; CHY_0491 .
GeneIDi 3727270.
KEGGi chy:CHY_0491.
PATRICi 21274131. VBICarHyd26463_0453.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CHYD246194:GJCN-492-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-2901 / DSM 6008.

Entry informationi

Entry nameiGCSPA_CARHZ
AccessioniPrimary (citable) accession number: Q3AET5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi