Reviewed, UniProtKB/Swiss-Prot Q3AEF5 (AROE_CARHZ)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	CHY_0623

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Shikimate dehydrogenase		PRO_0000325111
Regions
	Nucleotide binding	131 – 135	5	NADP By similarity
Sites
	Active site	71	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3AEF5-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: FFDAEE2500966396	FASTA	280	30,495
	10 20 30 40 50 60 MRINGETKLT GIIGYPLKHT LSPQMHNEAF KALNLNFLYL PLEVAEESLP QAIYGLKAFN 70 80 90 100 110 120 FRGINVTIPY KEKVFPFLDE VATEAKTIGA VNTIVHDRGR LIGYNTDAPG FLLSLKENDV 130 140 150 160 170 180 EVTGKKVLLL GAGGAARAVA YALLTAGAEL IIANRTIDKA KELAKDFQGV GKISEILELG 190 200 210 220 230 240 DKPISLAPYH MAVNTLPLGM HPYENQMPAV DFTGVTSDFV AYDLIYNPAE TKFLKASKEK 250 260 270 280 GARTINGLSM LLWQGVLAFE KWTGVSPPVK VMKKAIGLSC

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000141 Genomic DNA. Translation: ABB14147.1.
RefSeq	YP_359479.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3728671.
GenomeReviews	Gene locus CHY_0623 in contig CP000141_GR.
KEGG	chy:CHY_0623.
NMPDR	fig|246194.3.peg.366.
TIGR	CHY_0623.
Phylogenomic databases
HOGENOM	Q3AEF5.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_0623-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd. IPR011342. Quinate/shikimate_5-DHase. IPR013708. Shikimate_DHase-bd_N. IPR006151. Shikm_DHase/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_CARHZ

Accession

Primary (citable) accession number: Q3AEF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	November 22, 2005
Last modified:	November 25, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)