Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chemotaxis response regulator protein-glutamate methylesterase 1

Gene

cheB1

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601UniRule annotation
Active sitei187 – 1871UniRule annotation
Active sitei285 – 2851UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 1UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB1UniRule annotation
Ordered Locus Names:CHY_0968
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
Proteomesi
  • UP000002706 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Chemotaxis response regulator protein-glutamate methylesterase 1PRO_0000225452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 5614-aspartylphosphateUniRule annotation

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_0968.

Structurei

3D structure databases

ProteinModelPortaliQ3ADG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 122118Response regulatoryPROSITE-ProRule annotationAdd
BLAST
Domaini148 – 340193CheB-type methylesteraseUniRule annotationAdd
BLAST

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Sequence similaritiesi

Contains 1 cheB-type methylesterase domain.UniRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiVIMVSTM.
OrthoDBiPOG091H045J.

Family and domain databases

Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiPS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ADG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYKLFIVD DSALIRLRLK TSLALWPEIQ IVGEAENGQE ALKKIPLVKP
60 70 80 90 100
DVVTLDLEMP VLDGLSTLKE LNKVYPVPVI MLSSLTTHGA KATIEALENG
110 120 130 140 150
AVDFVPKDGD WNKVVSELKE KIKIAVLAKK RPKPFTGGTL NPKNVILGKN
160 170 180 190 200
GRQLVVIGAS TGGPPALREI IPKLPQTFPV PIVIIQHITR GFSKPLADQL
210 220 230 240 250
ARVSRLKVKE AEKDEQLLPG TVYVAPAGYT FKIDKQGGSL TAKIIEPVEY
260 270 280 290 300
LPAHFYPSVD EAMLSAAEVT GSKTIGVLLT GMGKDGALGM KAIKERGGYT
310 320 330 340
IAQDEETSVV YGMPKAAIDI GGVSRVLPLS AIAEEIAANI
Length:340
Mass (Da):36,528
Last modified:November 22, 2005 - v1
Checksum:iE613699C343E4340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB14452.1.
RefSeqiWP_011343891.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB14452; ABB14452; CHY_0968.
KEGGichy:CHY_0968.
PATRICi21275069. VBICarHyd26463_0918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB14452.1.
RefSeqiWP_011343891.1. NC_007503.1.

3D structure databases

ProteinModelPortaliQ3ADG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246194.CHY_0968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB14452; ABB14452; CHY_0968.
KEGGichy:CHY_0968.
PATRICi21275069. VBICarHyd26463_0918.

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiVIMVSTM.
OrthoDBiPOG091H045J.

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-967-MONOMER.

Family and domain databases

Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiPS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHEB1_CARHZ
AccessioniPrimary (citable) accession number: Q3ADG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.