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Protein

Chemotaxis response regulator protein-glutamate methylesterase 1

Gene

cheB1

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei160UniRule annotation1
Active sitei187UniRule annotation1
Active sitei285UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 1UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB1UniRule annotation
Ordered Locus Names:CHY_0968
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
Proteomesi
  • UP000002706 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254521 – 340Chemotaxis response regulator protein-glutamate methylesterase 1Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_0968.

Structurei

3D structure databases

ProteinModelPortaliQ3ADG9.
SMRiQ3ADG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 122Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini148 – 340CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiHPSVDVL.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ADG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYKLFIVD DSALIRLRLK TSLALWPEIQ IVGEAENGQE ALKKIPLVKP
60 70 80 90 100
DVVTLDLEMP VLDGLSTLKE LNKVYPVPVI MLSSLTTHGA KATIEALENG
110 120 130 140 150
AVDFVPKDGD WNKVVSELKE KIKIAVLAKK RPKPFTGGTL NPKNVILGKN
160 170 180 190 200
GRQLVVIGAS TGGPPALREI IPKLPQTFPV PIVIIQHITR GFSKPLADQL
210 220 230 240 250
ARVSRLKVKE AEKDEQLLPG TVYVAPAGYT FKIDKQGGSL TAKIIEPVEY
260 270 280 290 300
LPAHFYPSVD EAMLSAAEVT GSKTIGVLLT GMGKDGALGM KAIKERGGYT
310 320 330 340
IAQDEETSVV YGMPKAAIDI GGVSRVLPLS AIAEEIAANI
Length:340
Mass (Da):36,528
Last modified:November 22, 2005 - v1
Checksum:iE613699C343E4340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB14452.1.
RefSeqiWP_011343891.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB14452; ABB14452; CHY_0968.
KEGGichy:CHY_0968.

Similar proteinsi

Entry informationi

Entry nameiCHEB1_CARHZ
AccessioniPrimary (citable) accession number: Q3ADG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome