Q3AD96 (COMB_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	CHY_1042

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000072426

Sequences

	Sequence		Length	Mass (Da)
	Q3AD96 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: C0E9F95365049550	FASTA	238	25,782
	10 20 30 40 50 60 MKIDVLFYPE KLKNAEDKAV VVLDVLRATT TIATALAAGA EKIYPVSSIK EAFLLKKKIS 70 80 90 100 110 120 GALLGGERGG IKVPGFDLGN SPLEYQGLKG KTIILSSTNG TKTLKKAVSA RTLIAGSIVN 130 140 150 160 170 180 AKAVADYLLK LNLDVVLMPS GTDSQFSLED FAGAGYIISL LAEQKKIELS DQAYVSFELA 190 200 210 220 230 RSNPPEEILT RSFHGQRLIN LGFARDVEYC AKLNLLDVVP EGHLQEGRLV IESSRLFR

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000141 Genomic DNA. Translation: ABB15297.1.
RefSeq	YP_359888.1. NC_007503.1.
3D structure databases
ProteinModelPortal	Q3AD96.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AD96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3727400.
GenomeReviews	Gene locus CHY_1042 in contig CP000141_GR.
KEGG	chy:CHY_1042.
NMPDR	fig|246194.3.peg.725.
PATRIC	21275219. VBICarHyd26463_0992.
TIGR	CHY_1042.
Phylogenomic databases
eggNOG	COG2045.
HOGENOM	HBG633644.
OMA	DFICSGY.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_1042-MONOMER.
Family and domain databases
HAMAP	MF_00490. ComB. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. IPR022995. Pase_ComB. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
KO	K05979.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
SUPFAM	SSF142823. SSF142823. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_CARHZ

Accession

Primary (citable) accession number: Q3AD96

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program