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Q3AD62

- PUR5_CARHZ

UniProt

Q3AD62 - PUR5_CARHZ

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCHYD246194:GJCN-1075-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:CHY_1076
    OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
    Taxonomic identifieri246194 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
    ProteomesiUP000002706: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258345Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246194.CHY_1076.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3AD62.
    SMRiQ3AD62. Positions 3-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiPDMYGAD.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3AD62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEELTYKAAG VDIDAGMDVV RRIKSEVEKT LNPNVLAGIG GFSALYCLDV    50
    TGYNEPVLVS STDGVGTKLK IAQALGKYDT IGIDLVAMVV NDLLTVGAKP 100
    LFFLDYVAVG KLNPEQVADL VKGMAEGCLE ADCALVGGET AEMPGVYHPG 150
    DFDIAGFGVG VVEKSKIIDG SSVKAGDVII GVASSGIHSN GLSLARKALL 200
    EYGNYHLTAY VEEFGKTLGE ELLTPTRIYV KPVLDLMQKV EIKGMAHITG 250
    GGIVDNLPRI LPEKVEARIT VNWEIPKIFK LIEKAGNVPR REMWRTFNMG 300
    IGFILIVEEA KVQEAIKTLE SFNYKAWVIG EITAGERRVI INE 343
    Length:343
    Mass (Da):37,031
    Last modified:November 22, 2005 - v1
    Checksum:iC7BAFC7510FD2010
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000141 Genomic DNA. Translation: ABB15319.1.
    RefSeqiWP_011343998.1. NC_007503.1.
    YP_359922.1. NC_007503.1.

    Genome annotation databases

    EnsemblBacteriaiABB15319; ABB15319; CHY_1076.
    GeneIDi3727422.
    KEGGichy:CHY_1076.
    PATRICi21275287. VBICarHyd26463_1026.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000141 Genomic DNA. Translation: ABB15319.1 .
    RefSeqi WP_011343998.1. NC_007503.1.
    YP_359922.1. NC_007503.1.

    3D structure databases

    ProteinModelPortali Q3AD62.
    SMRi Q3AD62. Positions 3-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246194.CHY_1076.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB15319 ; ABB15319 ; CHY_1076 .
    GeneIDi 3727422.
    KEGGi chy:CHY_1076.
    PATRICi 21275287. VBICarHyd26463_1026.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi PDMYGAD.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci CHYD246194:GJCN-1075-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z-2901 / DSM 6008.

    Entry informationi

    Entry nameiPUR5_CARHZ
    AccessioniPrimary (citable) accession number: Q3AD62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3