Reviewed, UniProtKB/Swiss-Prot Q3AD53 (HISX_CARHZ)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23

Gene names

Name:	hisD
Ordered Locus Names:	CHY_1085

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Histidinol dehydrogenase		PRO_0000229854
Sites
	Active site	321	1	Proton acceptor By similarity
	Active site	322	1	Proton acceptor By similarity
	Metal binding	253	1	Zinc By similarity
	Metal binding	256	1	Zinc By similarity
	Metal binding	355	1	Zinc By similarity
	Metal binding	414	1	Zinc By similarity
	Binding site	231	1	Substrate By similarity
	Binding site	253	1	Substrate By similarity
	Binding site	256	1	Substrate By similarity
	Binding site	322	1	Substrate By similarity
	Binding site	355	1	Substrate By similarity
	Binding site	409	1	Substrate By similarity
	Binding site	414	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3AD53-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 7E7C1B94C7FE042C	FASTA	425	46,608
	10 20 30 40 50 60 MKLILNKEEL LDKYSRRKAV EEDIEQQVRK ILNEVASSGD EALIEYAREF DGFKGDLSNL 70 80 90 100 110 120 KVSEEEIDKA YREVDDGFLN SLRKAIQRVF DFHQKQLPRS WFTTEENGNI LGQIYTPVEV 130 140 150 160 170 180 AGIYVPGGTA AYPSSVVMNA VPAKVAGVKR IVMVSPQKGE RMNPYVLVAA REAGVTEIYR 190 200 210 220 230 240 VGGAHAIAAL AFGTKTIPRV DVITGPGNIY VTIAKKLVYG TVNIDMLAGP SEVVVIADSS 250 260 270 280 290 300 AKPEYLAADM LSQAEHDSLA SGVVITWDGE LARKTAQKVE EYLKLLPRRE IILKALENCG 310 320 330 340 350 360 GIVVVDDEEE ALQLANQLAP EHLELMLPNP FGYLAKVKNA GAVFLGQFSP EPMGDYLAGP 370 380 390 400 410 420 NHVLPTSGTS RFYSPLSVDN FLKKSSVIYY SQEGFLADAR DVIKLAETEG LFAHALSVKV RISNE

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000141 Genomic DNA. Translation: ABB15954.1.
RefSeq	YP_359931.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3728065.
GenomeReviews	Gene locus CHY_1085 in contig CP000141_GR.
KEGG	chy:CHY_1085.
NMPDR	fig|246194.3.peg.1132.
TIGR	CHY_1085.
Phylogenomic databases
HOGENOM	Q3AD53.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_1085-MON.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX_CARHZ

Accession

Primary (citable) accession number: Q3AD53

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 22, 2005
Last modified:	November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)