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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311SubstrateUniRule annotation
Metal bindingi253 – 2531ZincUniRule annotation
Binding sitei253 – 2531SubstrateUniRule annotation
Metal bindingi256 – 2561ZincUniRule annotation
Binding sitei256 – 2561SubstrateUniRule annotation
Active sitei321 – 3211Proton acceptorUniRule annotation
Active sitei322 – 3221Proton acceptorUniRule annotation
Binding sitei322 – 3221SubstrateUniRule annotation
Metal bindingi355 – 3551ZincUniRule annotation
Binding sitei355 – 3551SubstrateUniRule annotation
Binding sitei409 – 4091SubstrateUniRule annotation
Metal bindingi414 – 4141ZincUniRule annotation
Binding sitei414 – 4141SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: TIGR
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1084-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:CHY_1085
OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
ProteomesiUP000002706 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Histidinol dehydrogenasePRO_0000229854Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_1085.

Structurei

3D structure databases

ProteinModelPortaliQ3AD53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3AD53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLILNKEEL LDKYSRRKAV EEDIEQQVRK ILNEVASSGD EALIEYAREF
60 70 80 90 100
DGFKGDLSNL KVSEEEIDKA YREVDDGFLN SLRKAIQRVF DFHQKQLPRS
110 120 130 140 150
WFTTEENGNI LGQIYTPVEV AGIYVPGGTA AYPSSVVMNA VPAKVAGVKR
160 170 180 190 200
IVMVSPQKGE RMNPYVLVAA REAGVTEIYR VGGAHAIAAL AFGTKTIPRV
210 220 230 240 250
DVITGPGNIY VTIAKKLVYG TVNIDMLAGP SEVVVIADSS AKPEYLAADM
260 270 280 290 300
LSQAEHDSLA SGVVITWDGE LARKTAQKVE EYLKLLPRRE IILKALENCG
310 320 330 340 350
GIVVVDDEEE ALQLANQLAP EHLELMLPNP FGYLAKVKNA GAVFLGQFSP
360 370 380 390 400
EPMGDYLAGP NHVLPTSGTS RFYSPLSVDN FLKKSSVIYY SQEGFLADAR
410 420
DVIKLAETEG LFAHALSVKV RISNE
Length:425
Mass (Da):46,608
Last modified:November 21, 2005 - v1
Checksum:i7E7C1B94C7FE042C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB15954.1.
RefSeqiYP_359931.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB15954; ABB15954; CHY_1085.
KEGGichy:CHY_1085.
PATRICi21275305. VBICarHyd26463_1035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB15954.1.
RefSeqiYP_359931.1. NC_007503.1.

3D structure databases

ProteinModelPortaliQ3AD53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246194.CHY_1085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB15954; ABB15954; CHY_1085.
KEGGichy:CHY_1085.
PATRICi21275305. VBICarHyd26463_1035.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciCHYD246194:GJCN-1084-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-2901 / DSM 6008.

Entry informationi

Entry nameiHISX_CARHZ
AccessioniPrimary (citable) accession number: Q3AD53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2006
Last sequence update: November 21, 2005
Last modified: March 31, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.