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Q3ACY1

- UPPP_CARHZ

UniProt

Q3ACY1 - UPPP_CARHZ

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1157-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:CHY_1158
OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
ProteomesiUP000002706: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalUniRule annotationAdd
BLAST
Transmembranei76 – 9621HelicalUniRule annotationAdd
BLAST
Transmembranei99 – 11921HelicalUniRule annotationAdd
BLAST
Transmembranei173 – 19321HelicalUniRule annotationAdd
BLAST
Transmembranei206 – 22621HelicalUniRule annotationAdd
BLAST
Transmembranei238 – 25821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Undecaprenyl-diphosphatasePRO_0000227612Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_1158.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFVEQNAN.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ACY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSFQALILG LVQGLTEYLP VSSSGHLVLL QKIFGLKENV LLFDILVHLG
60 70 80 90 100
TLVPLLIIFR DEILAIIKKP WGRLPLLIIA GTVPTALIGL GFKDFFERLF
110 120 130 140 150
VSGSTLGIEF IITGLILWLA ERQKSGRKNL EKTTFLDAIF VGVAQGLAIL
160 170 180 190 200
PAISRSGLTI SGALIRGLNR EWAAKFSFLL SIPAILGAAV LDLKSFVEQN
210 220 230 240 250
ANLAGIDLMP FIVGFFAAML SGYFAVKFML EILRKGKLTW FSYYVWILGV
260
TILVLQAAGK F
Length:261
Mass (Da):28,612
Last modified:November 22, 2005 - v1
Checksum:iCDE390706A741F63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB16228.1.
RefSeqiWP_011344079.1. NC_007503.1.
YP_360003.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB16228; ABB16228; CHY_1158.
GeneIDi3728340.
KEGGichy:CHY_1158.
PATRICi21275456. VBICarHyd26463_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB16228.1 .
RefSeqi WP_011344079.1. NC_007503.1.
YP_360003.1. NC_007503.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246194.CHY_1158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB16228 ; ABB16228 ; CHY_1158 .
GeneIDi 3728340.
KEGGi chy:CHY_1158.
PATRICi 21275456. VBICarHyd26463_1110.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi FVEQNAN.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CHYD246194:GJCN-1157-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-2901 / DSM 6008.

Entry informationi

Entry nameiUPPP_CARHZ
AccessioniPrimary (citable) accession number: Q3ACY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3