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Protein
Submitted name:

Carbon monoxide dehydrogenase corrinoid/iron-sulfur protein, gamma subunit

Gene

acsC

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron-sulfur (4Fe-4S)UniRule annotationCombined sources
Metal bindingi18 – 181Iron-sulfur (4Fe-4S); via amide nitrogenCombined sources
Metal bindingi20 – 201Iron-sulfur (4Fe-4S)UniRule annotationCombined sources
Metal bindingi25 – 251Iron-sulfur (4Fe-4S)UniRule annotationCombined sources
Metal bindingi42 – 421Iron-sulfur (4Fe-4S)UniRule annotationCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

4Fe-4SUniRule annotationCombined sources, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1222-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Carbon monoxide dehydrogenase corrinoid/iron-sulfur protein, gamma subunitImported
Gene namesi
Name:acsCImported
Ordered Locus Names:CHY_1223Imported
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)Imported
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
Proteomesi
  • UP000002706 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-61272N.
STRINGi246194.CHY_1223.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H9AX-ray1.90A1-445[»]
2YCLX-ray1.95A1-445[»]
4C1NX-ray2.53A/C/E/G2-443[»]
ProteinModelPortaliQ3ACS3.
SMRiQ3ACS3. Positions 59-441.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3ACS3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 59594Fe-4SInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 4Fe-4S domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105EYX. Bacteria.
COG1456. LUCA.
HOGENOMiHOG000224304.
KOiK00197.
OMAiELTYYNP.
OrthoDBiEOG6QK4R1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR007202. 4Fe-4S_dom.
IPR016041. Ac-CoA_synth_d_su_TIM-brl.
IPR016218. AcylCoA_decarb/synth_gsu.
IPR013785. Aldolase_TIM.
IPR011005. Dihydropteroate_synth-like.
[Graphical view]
PfamiPF03599. CdhD. 1 hit.
PF04060. FeS. 1 hit.
[Graphical view]
PIRSFiPIRSF000376. AcCoA_decarb_gamma. 1 hit.
SUPFAMiSSF51717. SSF51717. 1 hit.
PROSITEiPS51656. 4FE4S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ACS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTGLEIYK HLPKKNCKEC GQPTCLAFAM QIAAGKAGLD ACPYVSDEAK
60 70 80 90 100
ELLESASAPP VALIKVGKGE KVLEIGHETV LFRHDKRFEH PCGLAILVED
110 120 130 140 150
TLSEGEIKER VEKINKLVFD RVGQMHSVNL VALKGSSQDA ATFAKAVATA
160 170 180 190 200
REVTDLPFIL IGTPEQLAAA LETEGANNPL LYAATADNYE QMVELAKKYN
210 220 230 240 250
VPLTVSAKGL DALAELVQKI TALGYKNLIL DPQPENISEG LFYQTQIRRL
260 270 280 290 300
AIKKLFRPFG YPTIAFALDE NPYQAVMEAS VYIAKYAGII VLNTVEPADI
310 320 330 340 350
LPLITLRLNI YTDPQKPIAV EPKVYEILNP GPDAPVFITT NFSLTYFCVA
360 370 380 390 400
GDVEGARIPA YILPVDTDGT SVLTAWAAGK FTPEKIAQFL KESGIAEKVN
410 420 430 440
HRKAILPGGV AVLSGKLQEL SGWEILVGPR ESSGINSFIK QRWNV
Length:445
Mass (Da):48,419
Last modified:November 22, 2005 - v1
Checksum:i4CB6629BD5020752
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB14598.1.
RefSeqiWP_011344137.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB14598; ABB14598; CHY_1223.
KEGGichy:CHY_1223.
PATRICi21275585. VBICarHyd26463_1169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB14598.1.
RefSeqiWP_011344137.1. NC_007503.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H9AX-ray1.90A1-445[»]
2YCLX-ray1.95A1-445[»]
4C1NX-ray2.53A/C/E/G2-443[»]
ProteinModelPortaliQ3ACS3.
SMRiQ3ACS3. Positions 59-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61272N.
STRINGi246194.CHY_1223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB14598; ABB14598; CHY_1223.
KEGGichy:CHY_1223.
PATRICi21275585. VBICarHyd26463_1169.

Phylogenomic databases

eggNOGiENOG4105EYX. Bacteria.
COG1456. LUCA.
HOGENOMiHOG000224304.
KOiK00197.
OMAiELTYYNP.
OrthoDBiEOG6QK4R1.

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1222-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ3ACS3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR007202. 4Fe-4S_dom.
IPR016041. Ac-CoA_synth_d_su_TIM-brl.
IPR016218. AcylCoA_decarb/synth_gsu.
IPR013785. Aldolase_TIM.
IPR011005. Dihydropteroate_synth-like.
[Graphical view]
PfamiPF03599. CdhD. 1 hit.
PF04060. FeS. 1 hit.
[Graphical view]
PIRSFiPIRSF000376. AcCoA_decarb_gamma. 1 hit.
SUPFAMiSSF51717. SSF51717. 1 hit.
PROSITEiPS51656. 4FE4S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-161 / DSM 6008 / Z-2901Imported.
  2. "Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis."
    Svetlitchnaia T., Svetlitchnyi V., Meyer O., Dobbek H.
    Proc. Natl. Acad. Sci. U.S.A. 103:14331-14336(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
  3. "Structural basis for electron and methyl-group transfer in a methyltransferase system operating in the reductive acetyl-CoA pathway."
    Goetzl S., Jeoung J.H., Hennig S.E., Dobbek H.
    J. Mol. Biol. 411:96-109(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR (4FE-4S).
  4. "ATP-induced electron transfer by redox-selective partner recognition."
    Hennig S.E., Goetzl S., Jeoung J.H., Bommer M., Lendzian F., Hildebrandt P., Dobbek H.
    Nat. Commun. 5:4626-4626(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.53 ANGSTROMS) OF 2-443 IN COMPLEX WITH IRON-SULFUR (4FE-4S).

Entry informationi

Entry nameiQ3ACS3_CARHZ
AccessioniPrimary (citable) accession number: Q3ACS3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.