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Q3ACM1

- ACDH_CARHZ

UniProt

Q3ACM1 - ACDH_CARHZ

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Protein
Acetaldehyde dehydrogenase
Gene
mhpF, CHY_1279
Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261Acyl-thioester intermediate By similarity
Binding sitei267 – 2671NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi157 – 1659NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1278-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Name:mhpF
Ordered Locus Names:CHY_1279
OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
ProteomesiUP000002706: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Acetaldehyde dehydrogenaseUniRule annotation
PRO_0000387646Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_1279.

Structurei

3D structure databases

ProteinModelPortaliQ3ACM1.
SMRiQ3ACM1. Positions 1-288.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHQGNVNM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ACM1-1 [UniParc]FASTAAdd to Basket

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MSNKIKAAII GPGNIGMDLM FKLMRSKYID VDTVVGIIPE SEGLALARKH    50
GKKTSAEGIK AILGNKDIKI VFDATSAKAH LKHAPLLEQD GKIAIDLTPA 100
AVGPYCVPAV TMEEQLNCKN VNMVTCAGQA TTPIVYAINK IADVKYAEIV 150
ATISSRSAGP GTRQNIDEFT ETTAKALEKI GGADKGKAII ILNPAEPPIM 200
MRNTIYTRVA NPDAPGIIEA IEEMVGKIKK YVPGYRLKVP PIIDGDKITT 250
IIEVEGEGAY LPKYAGNLDI ITAAAVAFAD EVAKKLLAEE QAKEVRAHG 299
Length:299
Mass (Da):31,888
Last modified:November 22, 2005 - v1
Checksum:i21257B5F6B1F0974
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB13885.1.
RefSeqiWP_011344189.1. NC_007503.1.
YP_360113.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB13885; ABB13885; CHY_1279.
GeneIDi3727086.
KEGGichy:CHY_1279.
PATRICi21275695. VBICarHyd26463_1223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB13885.1 .
RefSeqi WP_011344189.1. NC_007503.1.
YP_360113.1. NC_007503.1.

3D structure databases

ProteinModelPortali Q3ACM1.
SMRi Q3ACM1. Positions 1-288.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246194.CHY_1279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB13885 ; ABB13885 ; CHY_1279 .
GeneIDi 3727086.
KEGGi chy:CHY_1279.
PATRICi 21275695. VBICarHyd26463_1223.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HQGNVNM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci CHYD246194:GJCN-1278-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-2901 / DSM 6008.

Entry informationi

Entry nameiACDH_CARHZ
AccessioniPrimary (citable) accession number: Q3ACM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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