Reviewed, UniProtKB/Swiss-Prot Q3AC58 (RNC_CARHZ)

Names and origin

Protein names

Recommended name:
    Ribonuclease 3
    EC=3.1.26.3
Alternative name(s):
    Ribonuclease III
      Short name=RNase III

Gene names

Name:	rnc
Ordered Locus Names:	CHY_1444

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity.
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA processing Inferred from electronic annotation. Source: HAMAP rRNA catabolic process Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Ribonuclease 3 HAMAP MF_00104		PRO_0000228512
Regions
	Domain	6 – 135	130	RNase III
	Domain	162 – 231	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q3AC58-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 1579278C147E377E	FASTA	235	26,621
	10 20 30 40 50 60 MDKENLISLE KILGFNFNNP SILLSAITHP SYAFEHPEEG IEHNERLEFL GDAVLELFIS 70 80 90 100 110 120 DYLFRTFPQK SEGDLTKLRS RLVCAESLYE LAFKINLDKF LRLGKGEFKA GGNQRMSNLA 130 140 150 160 170 180 NAVEAVIGAV YFDCGIEAAF SFITRLYGEK LKPENLEQLP KDEKTTLQEL LQKEKNNVLR 190 200 210 220 230 YEILLEEGPP HQKIFTAGVI INDKLIATGR GKSKKEAEQE AAKKALELLK NEKEV

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000141 Genomic DNA. Translation: ABB15325.1.
RefSeq	YP_360276.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AC58.
Genome annotation databases
GeneID	3727428.
GenomeReviews	Gene locus CHY_1444 in contig CP000141_GR.
KEGG	chy:CHY_1444.
NMPDR	fig|246194.3.peg.1460.
TIGR	CHY_1444.
Phylogenomic databases
HOGENOM	Q3AC58.
OMA	ALTHKSF.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_1444-MON.
Family and domain databases
HAMAP	MF_00104. [Tree]
InterPro	IPR001159. Ds-RNA_bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_CARHZ

Accession

Primary (citable) accession number: Q3AC58

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)