Q3AC47 (ACKA_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	CHY_1455

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Acetate kinase HAMAP MF_00020		PRO_1000002218

Sequences

	Sequence		Length	Mass (Da)
	Q3AC47 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: E1E9AFE25C219FC6	FASTA	398	43,869
	10 20 30 40 50 60 MKVLVLNCGS SSLKYQLLDM EKETVLAKGL VERIGLEGSR LIIDLPGREK IKKEQPFVNH 70 80 90 100 110 120 EVAINAVLEE LVREEYGILR NLEEITAIGH RIVHGGEKFS GSVIINEEIL KAVEECVNLA 130 140 150 160 170 180 PLHNPPNILG IRACQKLLPN TPQVGVFDTA FHQTMPRKAY LYGVPYYWYE KYGIRRYGFH 190 200 210 220 230 240 GTSHKYVAYK ASEILGKPLN ELKIITCHLG NGSSVAAVKE GKSIDTSMGF TPLEGLLMGT 250 260 270 280 290 300 RSGNIDPAIV TFIQEKEGLS AAQVNDILNK KSGVLGISGY SDFRDIEERA SAGDDKAKLA 310 320 330 340 350 360 LEMFCYQVAK YIGAYAAAMN GVDAIVFTAG VGENSDVVRK EVCKYLEFLG ATLDEEKNKI 370 380 390 RGKEAIISTP DSKVKIMVIP TNEELMIAKE TLELVVNK

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000141 Genomic DNA. Translation: ABB13901.1.
RefSeq	YP_360287.1. NC_007503.1.
3D structure databases
ProteinModelPortal	Q3AC47.
SMR	Q3AC47. Positions 1-395.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AC47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3727063.
GenomeReviews	Gene locus CHY_1455 in contig CP000141_GR.
KEGG	chy:CHY_1455.
NMPDR	fig|246194.3.peg.1477.
PATRIC	21276041. VBICarHyd26463_1395.
TIGR	CHY_1455.
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	LIDMTNE.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_1455-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CARHZ

Accession

Primary (citable) accession number: Q3AC47

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program