Reviewed, UniProtKB/Swiss-Prot Q3AC14 (KGUA_CARHZ)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	CHY_1488

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Guanylate kinase HAMAP MF_00328		PRO_0000266301
Regions
	Domain	4 – 182	179	Guanylate kinase-like
	Nucleotide binding	11 – 18	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3AC14-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: BF350BF393EBD99B	FASTA	204	23,494
	10 20 30 40 50 60 MHKGMLVVVS GPSGAGKGTI CQEIRKRNPN LFYSISATTR EKRVGEIDGV HYYFIDRQQF 70 80 90 100 110 120 EKMIANDEFL EWADVYGNYY GTPKKPVFEA LARGQDVILE IDIKGARQVK KTYPEGVFVF 130 140 150 160 170 180 ILPPSISILE ERLRKRGTDK EEIIVKRMQM AWEEIANCDW YDYLILNDDL ETAVNDLEAV 190 200 LTAEKLKPKR VNYRVLLEGG VLER

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000141 Genomic DNA. Translation: ABB15039.1.
RefSeq	YP_360320.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AC14.
Genome annotation databases
GeneID	3727140.
GenomeReviews	Gene locus CHY_1488 in contig CP000141_GR.
KEGG	chy:CHY_1488.
NMPDR	fig|246194.3.peg.41.
TIGR	CHY_1488.
Phylogenomic databases
HOGENOM	Q3AC14.
OMA	DIDWQGT.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_1488-MON.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_CARHZ

Accession

Primary (citable) accession number: Q3AC14

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)