Reviewed, UniProtKB/Swiss-Prot Q3ABV0 (DEOC_CARHZ)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	deoC
Ordered Locus Names:	CHY_1552

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_0000231536
Sites
	Active site	159	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	188	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ABV0-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 157CC812C7990580	FASTA	228	24,175
	10 20 30 40 50 60 MVSSTKIAQM IDHTLLKATA TYADIEKLCQ EAKEFNFKSV CVNPAFVPFA SQLLKDSEIK 70 80 90 100 110 120 VCTVIGFPLG ATSTAVKAYE ASWAVENGAL EVDMVINIGA LKAGRYEEVL EDIKEVVSAA 130 140 150 160 170 180 KGKNPTVVVK VIIETCYLTD EEKIKACELA VEAGADFVKT STGFGTGGAT VEDVRLMKRT 190 200 210 220 VGEKAEVKAS GGIRSFADAI KMIEAGATRL GTSSGVSIMQ GLVSGEDY

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000141 Genomic DNA. Translation: ABB15923.1.
RefSeq	YP_360384.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ABV0.
Genome annotation databases
GeneID	3728034.
GenomeReviews	Gene locus CHY_1552 in contig CP000141_GR.
KEGG	chy:CHY_1552.
NMPDR	fig|246194.3.peg.1538.
TIGR	CHY_1552.
Phylogenomic databases
HOGENOM	Q3ABV0.
OMA	AKMIDHT.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_1552-MON.
Family and domain databases
HAMAP	MF_00114. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_CARHZ

Accession

Primary (citable) accession number: Q3ABV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)