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Q3ABA6

- PNP_CARHZ

UniProt

Q3ABA6 - PNP_CARHZ

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi497 – 4971MagnesiumUniRule annotation
Metal bindingi503 – 5031MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1757-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CHY_1758
OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
ProteomesiUP000002706: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Polyribonucleotide nucleotidyltransferasePRO_0000329576Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_1758.

Structurei

3D structure databases

ProteinModelPortaliQ3ABA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini564 – 62360KHUniRule annotationAdd
BLAST
Domaini633 – 70775S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiISMEDTH.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ABA6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTGRQILEK EIMIAGRPLK LTAGKVATQA SGSVLVSYGD TVVLVTATGS
60 70 80 90 100
KEPREGIDFF PLTVDYEERF YAVGKIPGGF IKREGRPSEK AILSARLIDR
110 120 130 140 150
PIRPLFPKGF KNDVHIVATV LSVNQDNPPE IAAMNGASAA LTLSHLPFLG
160 170 180 190 200
PIGAVVVGLV EDELVINPTI EQAEKSRLHL VVAGTRDAVM MVEAGAQEVP
210 220 230 240 250
EEIMIEAITR GHEEVKKIVA FIEEFREEAL KLGLAKEKME VVVEEKAELK
260 270 280 290 300
EAVTAEAYPL LKEAIEKIIA EKFNKQERDE YLENLKKELT TKFLETYPEE
310 320 330 340 350
ELTIKGILDS IQKEIVRQKI LKEGIRIDGR KTDEVRPIWC EVGLLPRTHG
360 370 380 390 400
SGLFTRGQTQ VLSIVTLGAV GDVQILDDLG IEESKRFMHH YNFPPYSVGE
410 420 430 440 450
VRPMRGPGRR EIGHGALAER ALEPVIPPEE VFPYTIRIVS EVLESNGSTS
460 470 480 490 500
MGSVCGSTLA LMDAGVPIKA PVAGVAMGLI KEGDEVAILT DIQGIEDALG
510 520 530 540 550
DMDFKVAGTK DGITALQMDI KIAGVTRDIL TKALAQAREG RMHILGKMLE
560 570 580 590 600
VISEPRKELS PYAPRIIFTT VDPEKIRDII GPGGKIIKKI IDETGVKIDI
610 620 630 640 650
EDDGRIFIAA VDKEAGEKAL NIIENLTKEI EVGKVYLGKV TRIADFGAFV
660 670 680 690 700
EVVPGVLGLP GKEGLVHISQ LAHSRVKRVE DVVKEGDQIL VKAIGYDNQG
710 720 730
RLKLSRKDAI PAEEVREKKN PPIHKPRREG K
Length:731
Mass (Da):80,115
Last modified:November 22, 2005 - v1
Checksum:i824F2934CBC49F01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB15621.1.
RefSeqiYP_360578.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB15621; ABB15621; CHY_1758.
GeneIDi3727728.
KEGGichy:CHY_1758.
PATRICi21276631. VBICarHyd26463_1679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB15621.1 .
RefSeqi YP_360578.1. NC_007503.1.

3D structure databases

ProteinModelPortali Q3ABA6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246194.CHY_1758.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB15621 ; ABB15621 ; CHY_1758 .
GeneIDi 3727728.
KEGGi chy:CHY_1758.
PATRICi 21276631. VBICarHyd26463_1679.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi ISMEDTH.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CHYD246194:GJCN-1757-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-2901 / DSM 6008.

Entry informationi

Entry nameiPNP_CARHZ
AccessioniPrimary (citable) accession number: Q3ABA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3