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Q3ABA6

- PNP_CARHZ

UniProt

Q3ABA6 - PNP_CARHZ

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, CHY_1758
Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi497 – 4971Magnesium By similarity
Metal bindingi503 – 5031Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1757-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:CHY_1758
OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
ProteomesiUP000002706: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329576Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_1758.

Structurei

3D structure databases

ProteinModelPortaliQ3ABA6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini564 – 62360KH
Add
BLAST
Domaini633 – 70775S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiISMEDTH.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ABA6-1 [UniParc]FASTAAdd to Basket

« Hide

MTTGRQILEK EIMIAGRPLK LTAGKVATQA SGSVLVSYGD TVVLVTATGS    50
KEPREGIDFF PLTVDYEERF YAVGKIPGGF IKREGRPSEK AILSARLIDR 100
PIRPLFPKGF KNDVHIVATV LSVNQDNPPE IAAMNGASAA LTLSHLPFLG 150
PIGAVVVGLV EDELVINPTI EQAEKSRLHL VVAGTRDAVM MVEAGAQEVP 200
EEIMIEAITR GHEEVKKIVA FIEEFREEAL KLGLAKEKME VVVEEKAELK 250
EAVTAEAYPL LKEAIEKIIA EKFNKQERDE YLENLKKELT TKFLETYPEE 300
ELTIKGILDS IQKEIVRQKI LKEGIRIDGR KTDEVRPIWC EVGLLPRTHG 350
SGLFTRGQTQ VLSIVTLGAV GDVQILDDLG IEESKRFMHH YNFPPYSVGE 400
VRPMRGPGRR EIGHGALAER ALEPVIPPEE VFPYTIRIVS EVLESNGSTS 450
MGSVCGSTLA LMDAGVPIKA PVAGVAMGLI KEGDEVAILT DIQGIEDALG 500
DMDFKVAGTK DGITALQMDI KIAGVTRDIL TKALAQAREG RMHILGKMLE 550
VISEPRKELS PYAPRIIFTT VDPEKIRDII GPGGKIIKKI IDETGVKIDI 600
EDDGRIFIAA VDKEAGEKAL NIIENLTKEI EVGKVYLGKV TRIADFGAFV 650
EVVPGVLGLP GKEGLVHISQ LAHSRVKRVE DVVKEGDQIL VKAIGYDNQG 700
RLKLSRKDAI PAEEVREKKN PPIHKPRREG K 731
Length:731
Mass (Da):80,115
Last modified:November 22, 2005 - v1
Checksum:i824F2934CBC49F01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB15621.1.
RefSeqiYP_360578.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB15621; ABB15621; CHY_1758.
GeneIDi3727728.
KEGGichy:CHY_1758.
PATRICi21276631. VBICarHyd26463_1679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000141 Genomic DNA. Translation: ABB15621.1 .
RefSeqi YP_360578.1. NC_007503.1.

3D structure databases

ProteinModelPortali Q3ABA6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246194.CHY_1758.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB15621 ; ABB15621 ; CHY_1758 .
GeneIDi 3727728.
KEGGi chy:CHY_1758.
PATRICi 21276631. VBICarHyd26463_1679.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi ISMEDTH.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CHYD246194:GJCN-1757-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z-2901 / DSM 6008.

Entry informationi

Entry nameiPNP_CARHZ
AccessioniPrimary (citable) accession number: Q3ABA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 22, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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