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Q3AB88 (Q3AB88_CARHZ) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase HAMAP-Rule MF_00159
EC=1.17.7.1 HAMAP-Rule MF_00159
Alternative name(s):
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase HAMAP-Rule MF_00159
Gene names
Name:ispG HAMAP-Rule MF_00159
Ordered Locus Names:CHY_1776
OrganismCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP] EMBL ABB16075.1
Taxonomic identifier246194 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Carboxydothermus ›

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate By similarity. HAMAP-Rule MF_00159 SAAS SAAS016425

Catalytic activity

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. HAMAP-Rule MF_00159 SAAS SAAS011005

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP-Rule MF_00159

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6. HAMAP-Rule MF_00159 SAAS SAAS011005

Sequence similarities

Belongs to the IspG family. HAMAP-Rule MF_00159

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2661Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00159
Metal binding2691Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00159
Metal binding3011Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00159
Metal binding3081Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00159

Sequences

Sequence LengthMass (Da)Tools
Q3AB88 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 2A7C5E464ABECC17

FASTA35538,548
        10         20         30         40         50         60 
MLLPRRKTKT IFIGTVPVGG DAPITVQSMT NTDTRDWQKT LRQIKRLKKA GCELVRVAVP 

        70         80         90        100        110        120 
DQEAARALKL IVEKSPLPVI ADIHFDYKLA LMALEAGVHG LRLNPGNIGS AEKVRIIVRE 

       130        140        150        160        170        180 
AKNRRVPIRI GVNAGSLEKK LVEKYGGITP EAMVESALHH VGILEDMGFD LIKISLKASD 

       190        200        210        220        230        240 
IPLMLAAYRL LAKKVDYPFH IGVTEAGPRS TGIIKSAVGI GALLAEGIGD TLRVSLTADP 

       250        260        270        280        290        300 
VEEVKIGFQI LKALGLREYG AEVISCPTCG RTQVDIIKIA REVEKFAQNV KKPLKIAVMG 

       310        320        330        340        350 
CVVNGPGEAR EADIGIAGGR GEALLFKKGK VVRKIGEEEI LKVLKEEIKK LEEEV

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References

[1]"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901."
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.
PLoS Genet. 1:563-574(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000141 Genomic DNA. Translation: ABB16075.1.
RefSeqYP_360596.1. NC_007503.1.

3D structure databases

ProteinModelPortalQ3AB88.
ModBaseSearch...

Protein-protein interaction databases

STRING246194.CHY_1776.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB16075; ABB16075; CHY_1776.
GeneID3728187.
KEGGchy:CHY_1776.
PATRIC21276663. VBICarHyd26463_1695.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0821.
HOGENOMHOG000261017.
KOK03526.
OMAPRKLEIV.
ProtClustDBCLSK2772364.

Enzyme and pathway databases

BioCycCHYD246194:GJCN-1775-MONOMER.
UniPathwayUPA00056; UER00096.

Family and domain databases

HAMAPMF_00159. IspG.
InterProIPR011005. Dihydropteroate_synth-like.
IPR016425. IspG_bac.
IPR004588. IspG_bac-typ.
[Graphical view]
PfamPF04551. GcpE. 1 hit.
[Graphical view]
PIRSFPIRSF004640. IspG. 1 hit.
SUPFAMSSF51717. DHP_synth_like. 1 hit.
TIGRFAMsTIGR00612. ispG_gcpE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ3AB88_CARHZ
AccessionPrimary (citable) accession number: Q3AB88
Entry history
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info