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Protein

Tyrosine recombinase XerC

Gene

xerC

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431UniRule annotation
Active sitei167 – 1671UniRule annotation
Active sitei236 – 2361UniRule annotation
Active sitei239 – 2391UniRule annotation
Active sitei262 – 2621UniRule annotation
Active sitei271 – 2711O-(3'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Chromosome partitionUniRule annotationSAAS annotation, DNA integrationUniRule annotationSAAS annotation, DNA recombinationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine recombinase XerCUniRule annotation
Gene namesi
Name:xerCUniRule annotationImported
Ordered Locus Names:CHY_1792Imported
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)Imported
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
ProteomesiUP000002706 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.UniRule annotation

Protein-protein interaction databases

STRINGi246194.CHY_1792.

Structurei

3D structure databases

ProteinModelPortaliQ3AB72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family. XerC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4974.
HOGENOMiHOG000045294.
KOiK03733.
OMAiTHISFER.
OrthoDBiEOG6PZXFP.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
TIGRFAMsiTIGR02225. recomb_XerD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3AB72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEELKAFLN YLLLERNYSP NTIAAYERDI LDFQEFLQGK SFLSVNEVDL
60 70 80 90 100
KQFLVDILRK NRSRRTAARK MVALRSFYRF LKRCGFIKEN PALSLEIPKI
110 120 130 140 150
PKTLPEVLTV DEVFKVIEGQ ENSTPTGLRN RALLELFYGA GLRIGEIAGL
160 170 180 190 200
TLNDLDLTQG YVRVTGKGRR QRIVPLGKYA LDSLKLYLEA GRPAFKPKSE
210 220 230 240 250
KLFLNQQGAG LTVRGIRYLI SQIVKKAGLN RKITPHTFRH SYATHLLEGG
260 270 280 290
ADIRAVQELL GHKRLSTTEI YTHLSKERLR EVYLRTHPRS REEKNDV
Length:297
Mass (Da):34,072
Last modified:November 22, 2005 - v1
Checksum:iCE718CACD3458A37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB15009.1.
RefSeqiWP_011344686.1. NC_007503.1.
YP_360612.1. NC_007503.1.

Genome annotation databases

EnsemblBacteriaiABB15009; ABB15009; CHY_1792.
KEGGichy:CHY_1792.
PATRICi21276695. VBICarHyd26463_1711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA. Translation: ABB15009.1.
RefSeqiWP_011344686.1. NC_007503.1.
YP_360612.1. NC_007503.1.

3D structure databases

ProteinModelPortaliQ3AB72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246194.CHY_1792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB15009; ABB15009; CHY_1792.
KEGGichy:CHY_1792.
PATRICi21276695. VBICarHyd26463_1711.

Phylogenomic databases

eggNOGiCOG4974.
HOGENOMiHOG000045294.
KOiK03733.
OMAiTHISFER.
OrthoDBiEOG6PZXFP.

Enzyme and pathway databases

BioCyciCHYD246194:GJCN-1791-MONOMER.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
TIGRFAMsiTIGR02225. recomb_XerD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-161 / DSM 6008 / Z-2901Imported.

Entry informationi

Entry nameiQ3AB72_CARHZ
AccessioniPrimary (citable) accession number: Q3AB72
Entry historyi
Integrated into UniProtKB/TrEMBL: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 24, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.