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Reviewed, UniProtKB/Swiss-Prot Q3AB25 (GLPK_CARHZ)

Last modified June 16, 2009. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: CHY_1839
OrganismCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]
Taxonomic identifier246194 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

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Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Glycerol kinase HAMAP MF_00186
PRO_1000020716

Regions

Nucleotide binding411 – 4155ATP By similarity

Sites

Binding site131Substrate By similarity
Binding site171ATP By similarity
Binding site831Substrate By similarity
Binding site1351Substrate By similarity
Binding site2451Substrate By similarity
Binding site2671ATP By similarity
Binding site3101ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3AB25-1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: DBE174C15DC906D7

FASTA50055,606
        10         20         30         40         50         60 
MTKKYVLALD QGTTSCRAIL FDRDSNIVGV AQKEFTQHYP KPGWVEHDPE EIWSTQYGVI 

        70         80         90        100        110        120 
AELMARYNVN PEEIAAIGIT NQRETTVVWD RNTGKPVYNA IVWQCRRTAG ICDELKAKGL 

       130        140        150        160        170        180 
EEKVRYKTGL VIDAYFSGTK IKWILDNVEG AREKAERGEL LFGTIDTWLV WKLTGGKVHV 

       190        200        210        220        230        240 
TDYSNASRTM IYNIRELKWD EELLAELGIP ASMLPEVKPS SYVYGETDPN VFFGHAIPIS 

       250        260        270        280        290        300 
GIAGDQQAAL FGQTCFEPGM AKNTYGTGCF MLMNTGDKVY ESKNGLLTTI AWGIDGKVEY 

       310        320        330        340        350        360 
ALEGSIFIAG AVIQWLRDGL KLIESAADSE YFASKVPDTG GVYIVPAFAG LGAPYWDMRA 

       370        380        390        400        410        420 
RGTIVGLTRG TNKYHLVRAA LESMAYQTRD VLSAMEADSG IKLQALKVDG GAVANNLLMQ 

       430        440        450        460        470        480 
FQADILGVPV ERPVNIETTA MGAAYLAGLA VGFWADKQEL VAKYKVSRRF EPTMDEQTRE 

       490        500 
KLYKGWQRAV TRAREWEVEE

« Hide

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References

[1]"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901."
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.
PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000141 Genomic DNA. Translation: ABB15269.1.
RefSeqYP_360659.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3727372.
GenomeReviewsGene locus CHY_1839 in contig CP000141_GR.
KEGGchy:CHY_1839.
NMPDRfig|246194.3.peg.2378.
TIGRCHY_1839.

Phylogenomic databases

HOGENOMQ3AB25.
OMAQ3AB25. RQTSGIC.

Enzyme and pathway databases

BioCycCHYD246194:CHY_1839-MON.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_CARHZ
AccessionPrimary (citable) accession number: Q3AB25
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 22, 2005
Last modified: June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents