Reviewed, UniProtKB/Swiss-Prot Q3AAV5 (KHSE_CARHZ)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	CHY_1910

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Homoserine kinase HAMAP MF_00384		PRO_1000049119
Regions
	Nucleotide binding	86 – 96	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3AAV5-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 36BED25B8E3A36D4	FASTA	304	32,790
	10 20 30 40 50 60 MVCVLIPATS ANLGPGFDAV GMALSFYNEV SLGPSPKELE IEVFGDGAEL ISRDKNNLVY 70 80 90 100 110 120 VAITKIFERL GKTPRNLKLT LKNRVPLARG LGSSAAAIVG GLVAANAYLG NPLPKDELLR 130 140 150 160 170 180 LATELEGHPD NVAPALLGGV VVSGFDRDKV KYLKLPVPEV EVVVAIPKFQ LKTADSRQIL 190 200 210 220 230 240 PAEIPFSQAV LNVNRVSFLI AAFCLKKYEY LQIGMEDYLH QPYRSQLIPG FYQVVEEAKK 250 260 270 280 290 300 AGAYGVALSG SGPTVIALAR EGKAVGRAIE ETFLNFGVEA EIIYTRPEER GAIDLINYKG EGDC

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000141 Genomic DNA. Translation: ABB14267.1.
RefSeq	YP_360729.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AAV5.
Genome annotation databases
GeneID	3728636.
GenomeReviews	Gene locus CHY_1910 in contig CP000141_GR.
KEGG	chy:CHY_1910.
NMPDR	fig|246194.3.peg.2529.
TIGR	CHY_1910.
Phylogenomic databases
HOGENOM	Q3AAV5.
OMA	FDCLGAA.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_1910-MON.
Family and domain databases
HAMAP	MF_00384. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR000870. Homoserine_kin. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_CARHZ

Accession

Primary (citable) accession number: Q3AAV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)