Reviewed, UniProtKB/Swiss-Prot Q3AAT6 (HIS82_CARHZ)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	CHY_1929

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000230212
Amino acid modifications
	Modified residue	222	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3AAT6-1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 340560EE04AE06F3	FASTA	362	40,662
	10 20 30 40 50 60 MVRKALENLK PYVPGKPVEE VERELGITNI DKLASNENLW GISPKVAAAI KEAVDKVNYY 70 80 90 100 110 120 PDGGAFRLKE KIAAKYGVTP DNIILGNGSD ELVMFLAMAL IDPGDEAIMP VPSFPRYEPV 130 140 150 160 170 180 VTMMNGIARE IPLKEHRLDL KTMAEAVNEK TRLVYLCNPN NPTGTYITKG ELEEFLERVP 190 200 210 220 230 240 EEVVVVLDEA YFEFARLFND YPDGLNFFKK RPNTVVLRTF SKAYGLAGLR VGYGFAPENL 250 260 270 280 290 300 AKAINSLRPP FNVNFLAQMA AVAALDDEEY VREVVKNTDE GKKFLYQEII RMGLSYIPSA 310 320 330 340 350 360 ANFLMIKTEK PSALVFRELL KRGVIVRSGD IFGMDDWIRV TVGTPVQNAR FINELKMVLE IL

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000141 Genomic DNA. Translation: ABB16170.1.
RefSeq	YP_360748.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AAT6.
Genome annotation databases
GeneID	3728282.
GenomeReviews	Gene locus CHY_1929 in contig CP000141_GR.
KEGG	chy:CHY_1929.
NMPDR	fig|246194.3.peg.2575.
TIGR	CHY_1929.
Phylogenomic databases
HOGENOM	Q3AAT6.
OMA	KGYIVRS.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_1929-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001176. ACC_synthase. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_CARHZ

Accession

Primary (citable) accession number: Q3AAT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 22, 2005
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)