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Q3AAN2

- NADK_CARHZ

UniProt

Q3AAN2 - NADK_CARHZ

Protein

NAD kinase

Gene

nadK

Organism
Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei60 – 601Proton acceptorUniRule annotation
    Binding sitei145 – 1451NADUniRule annotation
    Binding sitei164 – 1641NADUniRule annotation
    Binding sitei234 – 2341NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi60 – 612NADUniRule annotation
    Nucleotide bindingi134 – 1352NADUniRule annotation
    Nucleotide bindingi175 – 1806NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCHYD246194:GJCN-1982-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:CHY_1983
    OrganismiCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008)
    Taxonomic identifieri246194 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
    ProteomesiUP000002706: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280NAD kinasePRO_0000229622Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246194.CHY_1983.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3AAN2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiRWEALCL.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3AAN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKDKKLGPI LLEKIMEKAR DYDFLLKNRY LVSGECGIVE IAEIDEKTEK    50
    IDLVLVLGGD GTILCATRYF APKAIPILGI NLGQLGYLSE LDPQEIDFGL 100
    QKIRAGEYLV EDRTMLEARV RRANQEVAVF YGLNDGVLTK GAFARIINFA 150
    VFVDEQYITE YAADGVIVAT PTGSTAYSLS AGGAILDPEV KAFIITPICP 200
    HTLAARSLVV ADDKEIRIVV KTALESSMLT VDGQQGFGIK PGDEIIIKKA 250
    PYQAKFIKLK NRSFYQLLRE KMREANRYHD 280
    Length:280
    Mass (Da):31,111
    Last modified:November 22, 2005 - v1
    Checksum:iCB34D935A5F85910
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000141 Genomic DNA. Translation: ABB14078.1.
    RefSeqiWP_011344875.1. NC_007503.1.
    YP_360802.1. NC_007503.1.

    Genome annotation databases

    EnsemblBacteriaiABB14078; ABB14078; CHY_1983.
    GeneIDi3726381.
    KEGGichy:CHY_1983.
    PATRICi21277053. VBICarHyd26463_1889.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000141 Genomic DNA. Translation: ABB14078.1 .
    RefSeqi WP_011344875.1. NC_007503.1.
    YP_360802.1. NC_007503.1.

    3D structure databases

    ProteinModelPortali Q3AAN2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246194.CHY_1983.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB14078 ; ABB14078 ; CHY_1983 .
    GeneIDi 3726381.
    KEGGi chy:CHY_1983.
    PATRICi 21277053. VBICarHyd26463_1889.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi RWEALCL.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CHYD246194:GJCN-1982-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z-2901 / DSM 6008.

    Entry informationi

    Entry nameiNADK_CARHZ
    AccessioniPrimary (citable) accession number: Q3AAN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3