Q3AAE9 (MURA1_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
EC=2.5.1.7

Alternative name(s):
Enoylpyruvate transferase 1
UDP-N-acetylglucosamine enolpyruvyl transferase 1
Short name=EPT 1

Gene names

Name:	murA1
Synonyms:	murAB
Ordered Locus Names:	CHY_2066

Organism

Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]

Taxonomic identifier

246194 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP MF_00111
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable HAMAP MF_00111.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000231186
Sites
	Active site	115	1	Proton donor By similarity
Amino acid modifications
	Modified residue	115	1	2-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3AAE9 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 7639D3D2F2F0C842	FASTA	420	45,378
	10 20 30 40 50 60 MEKFFIVGSH GLKGEIKVSG AKNSALPIIA ATLLTREPCV LENIPKLEDV NIMLSILKRL 70 80 90 100 110 120 GSKVEFGQLL TIQNNRINEL IIPEELARKI RASNLFLGPL VARFQEGVVP LPGGCNIGNR 130 140 150 160 170 180 PMDLHLKGLR LMGAEVEEKS GFIRARAKKL KGAEIHLDFP SVGATENLMM AAALAQGTTI 190 200 210 220 230 240 IRNAAREPEI VDLQNFLNLM GAKVKGAGTD IIKITGVNQL KGVTHKIIPD RIEAGTHMVM 250 260 270 280 290 300 AAATQSDIII SGVIPEHLEA VMAKLKEAGA LITSGGDWVR VTGKSIIKPV DIKTMPYPGF 310 320 330 340 350 360 PTDMQPQILA LLTLAQGTSI ISEGVFDNRF KHVEELRRMG ADIRLESRIA VIKGVPKLTG 370 380 390 400 410 420 ASVIAHDLRA AAALVIAGLA AEGMTVLEGI KNLDRGYENL DLKYQLIGAQ IKRVNGEEKY

References

[1]

"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901." Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A. PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z-2901 / DSM 6008.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000141 Genomic DNA. Translation: ABB14857.1.
RefSeq	YP_360885.1. NC_007503.1.
3D structure databases
ProteinModelPortal	Q3AAE9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3AAE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3726584.
GenomeReviews	Gene locus CHY_2066 in contig CP000141_GR.
KEGG	chy:CHY_2066.
NMPDR	fig|246194.3.peg.1854.
PATRIC	21277213. VBICarHyd26463_1969.
TIGR	CHY_2066.
Phylogenomic databases
eggNOG	COG0766.
HOGENOM	HBG482701.
OMA	ADIRLES.
Enzyme and pathway databases
BioCyc	CHYD246194:CHY_2066-MONOMER.
Family and domain databases
HAMAP	MF_00111. MurA. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00790.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01072. MurA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_CARHZ

Accession

Primary (citable) accession number: Q3AAE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program