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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi115 – 121ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCHYD246194:G1G5B-1934-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:CHY_2071
OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Taxonomic identifieri246194 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
Proteomesi
  • UP000002706 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002571751 – 451UDP-N-acetylmuramoylalanine--D-glutamate ligaseAdd BLAST451

Interactioni

Protein-protein interaction databases

STRINGi246194.CHY_2071

Structurei

3D structure databases

SMRiQ3AAE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMZ Bacteria
COG0771 LUCA
HOGENOMiHOG000049428
KOiK01925
OMAiVDKGNDY
OrthoDBiPOG091H002Z

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00639 MurD, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR005762 UDP-N-AcMur-Glu_ligase
PfamiView protein in Pfam
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01087 murD, 1 hit

Sequencei

Sequence statusi: Complete.

Q3AAE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGLYTNKRI LVVGAGKSGR AAAAFLIKRG AKVVLTDKKM SLPVDEELKK
60 70 80 90 100
LAEEGVELVL GGYPLVKDWE LLVVSPGVPL TEEPIAYSLK EGIPVLGEIE
110 120 130 140 150
LAYKELKAPI IAVTGTNGKT TTTSWIGEVL KIAGFKTLIA GNIGYPLIEA
160 170 180 190 200
VEEEWDAVSL EVSSFQLETI KSFKPKVAVL LNLTPDHLDR HKTLEGYLEA
210 220 230 240 250
KARIFINQDR TDVTVLNYDD PRIRSLGRKT PGRVFYFSQK EELEEGVFVK
260 270 280 290 300
KGKIVVRSLG VEEEIIDIEN LPLPGPHNLE NALATVAACW SFGVSGKNIE
310 320 330 340 350
RGLRNFQGVA HRLEKVAEIN GVLYVNDSKG TNPDSTIKAL NSYERPIVLI
360 370 380 390 400
AGGRNKGNSF GELAREIREK VRFTILVGEC REELKEALEM VGYDKYVVAE
410 420 430 440 450
SFEDAVKKAK ELARPGDVVL LSPAAASWDM FKNYEERGEL FKRLVLNMVE

G
Length:451
Mass (Da):49,844
Last modified:November 22, 2005 - v1
Checksum:i6C1A216644F07CF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000141 Genomic DNA Translation: ABB13926.1
RefSeqiWP_011344963.1, NC_007503.1

Genome annotation databases

EnsemblBacteriaiABB13926; ABB13926; CHY_2071
KEGGichy:CHY_2071

Similar proteinsi

Entry informationi

Entry nameiMURD_CARHZ
AccessioniPrimary (citable) accession number: Q3AAE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health